ProGP170

Home -> ProGPdb -> Search ProGP -> Display data

ProGP ID ProGP170
Validation Status Uncharacterized
Organism Information
Organism NameClostridium difficile C253
Domain Bacteria
Classification Family: Clostridiaceae
Order: Clostridiales
Class: Clostridia
Division or phylum: "Firmicutes"
Genome Sequence(s)
Organism Additional Information Clostridium difficile is a gram-positive, anaerobic, spore-forming bacterium that produces TcdA and TcdB toxins causing severe tissue damage. It ia an opportunistic pathogen that is the major cause of antibiotic-associated diarrhoea and pseudomembranous colitis in humans. C. dificile infection can also result in abdominal pain, inflammation, and ulceration of the lining of the intestinal wall.
Protein Information
Protein NameSurface layer glycoproteins
Subcellular LocationSurface
Function Two glycoproteins P36 and P47 are the components of the S-layer.
Glycosylation Status
Glycosylation Type Information currently not available with us.
Glycosite Sequence Logo
Technique(s) used for Glycosylation DetectionDIG glycan/protein double labeling kit and thymol staining method.
Literature
Year of Identification1999
Year of Identification Month Wise1999.5
ReferenceDepartment of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, 00161, Italy.
ReferenceKarjalainen, T., Waligora-Dupriet, A.J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P. and Mastrantonio, P. (2001) Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile. Infect Immun, 69, 3442-3446. [PubMed: 11292772]
AuthorKarjalainen, T., Waligora-Dupriet, A.J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P. Mastrantonio, P.
Research GroupDépartement de Microbiologie, Faculté de Pharmacie, Université de Paris-Sud, 92296 Châtenay-Malabry Cedex, France
Corresponding Author Mastrantonio, P.
ContactDépartement de Microbiologie, Faculté de Pharmacie, Université de Paris-Sud, 92296 Châtenay-Malabry Cedex, France
Reference1) Calabi, E., Ward, S., Wren, B., Paxton, T., Panico, M., Morris, H., Dell, A., Dougan, G. and Fairweather, N. (2001) Molecular characterization of the surface layer proteins from Clostridium difficile. Mol Microbiol, 40, 1187-1199. [PubMed: 11401722]
AuthorCalabi E1, Ward S, Wren B, Paxton T, Panico M, Morris H, Dell A, Dougan G, Fairweather N.
Research GroupDepartment of Biology and Biochemistry, Imperial College, South Kensington, London SW7 2AY, UK.
Corresponding Author Fairweather N.
ContactDepartment of Biology and Biochemistry, Imperial College, South Kensington, London SW7 2AY, UK.
Authorhttps://www.ncbi.nlm.nih.gov/pubmed/ 10839973
Research GroupCerquetti, M., Molinari, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C. Mastrantonio, P.
Corresponding Author Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, 00161, Italy.
Contact Mastrantonio, P.