ProGP195

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ProGP ID ProGP195
Validation Status Uncharacterized
Organism Information
Organism NameMycobacterium vaccae
Domain Bacteria
Classification Family: Mycobacteriaceae
Suborder: Corynebacterineae
Order: Actinomycetales
Subclass: Actinobacteridae
Class: Actinobacteria
Division or phylum: "Actinobacteria"
Protein Information
Protein NamePS4A (water soluble protein- polysaccharide)
Subcellular LocationIntracellular
Function PS4A significantly decreased tumor incidence in vivo, produced activation of murine peritoneal macrophages. However, the antineoplastic activity was only attributable to the high molecular weight fraction of the protein-polysaccharia complex. The low molecular weight fraction had no antineoplastic activity in viva despite stimulation of TNF-a production in vitro. In vitro experiments also demonstrated that although all PS4A components significantly increased TNF-α production by macrophages, the high molecular weight fraction stimulated more IL-1 production, indicating a better immunostimulating activity.
Literature
Year of Identification2000
Year of Identification Month Wise2000.06
ReferenceTian, X.X., Li, A., Zhou, W., Farrugia, I.V. and Groves, M.J. (1999) Isolation and biological activities of an antineoplastic protein-polysaccharide complex (PS4A) obtained from Mycobacterium vaccae. Anticancer Res, 19, 237-243. [PubMed: 10226548]
AuthorTian, X.X., Li, A., Zhou, W., Farrugia, I.V. Groves, M.J.
Research GroupInstitute for Tuberculosis Research (M/C 964), College of Pharmacy, University of Illinois at Chicago 60607, USA.
Corresponding Author Groves, M.J.
ContactInstitute for Tuberculosis Research (M/C 964), College of Pharmacy, University of Illinois at Chicago 60607, USA.
Reference1) Tian, X.X., Li, A., Farrugia, I.V., Mo, X., Crich, D. and Groves, M.J. (2000) Isolation and identification of poly-alpha-(1-->4)-linked 3-O-methyl-D-mannopyranose from a hot-water extract of Mycobacterium vaccae. Carbohydr Res, 324, 38-44. [PubMed: 10723610]
Author Tian, X.X., Li, A., Farrugia, I.V., Mo, X., Crich, D. Groves, M.J.
Research GroupInstitute for Tuberculosis Research, University of Illinois at Chicago 60612, USA.
Corresponding Author Groves, M.J.
ContactInstitute for Tuberculosis Research, University of Illinois at Chicago 60612, USA.