ProGP254

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ProGP ID ProGP254
Validation Status Uncharacterized
Organism Information
Organism NameParabacteroides (Bacteroides) distasonis
Domain Bacteria
Classification Family: Porphyromonadaceae
Order: Bacteroidales
Class: Bacteroidia
Division or phylum: "Bacteroidetes"
Gene Information
Gene NamedgpC
Protein Information
Protein NameDgpC
Subcellular LocationSurface
Function Most likely to be an S-layer glycoprotein as evidenced by its abundance, its similarity to known S-layers, its surface extraction and presence of an S-layer lattice on the organism.
Glycosylation Status
Glycosylation Type Information currently not available with us.
Glycosite Sequence Logo
Technique(s) used for Glycosylation DetectionPro-Q Emerald 300 Glycoprotein staining and AAL (Aleuria aurantia lectin) affinity chromatography
Glycan Information
Glycan Annotation Glycan represents 2.1% (wt/wt) of the molecule. It is composed almost entirely of xylose (89.6%). Glucose (6.9%), mannose (2.2%), and rhamnose (1.3%) are present in small amounts. 16 xylose residues and one or two glucose or other six-carbon sugar have been calculated per DgpC molecule. Glycosyl linkage analysis has shown that the xylose molecules are largely linked 1,2 and 1,4.
Literature
Additional CommentExpression of Dgp glycoproteins is phase-variable in the normal environment of bacteria.
Year of Identification2007
Year of Identification Month Wise2007.02
Reference1) Fletcher, C.M., Coyne, M.J., Bentley, D.L., Villa, O.F. and Comstock, L.E. (2007) Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem. Proc Natl Acad Sci U S A, 104, 2413-2418. [PubMed: 17284602]
Author Comstock, L.E.
Research GroupChanning Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Corresponding Author Fletcher, C.M., Coyne, M.J., Bentley, D.L., Villa, O.F. Comstock, L.E.
ContactChanning Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.