ProGP349

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ProGP ID ProGP349
Validation Status Uncharacterized
Organism Information
Organism NamePorphyromonas gingivalis
Domain Bacteria
Classification Family: "Porphyromonadaceae"
Order: "Bacteroidales"
Class: "Bacteroidia"
Division or phylum: "Bacteroidetes"
Taxonomic ID (NCBI) 837
Genome Sequence(s)
GenBank AP009380.1
EMBL AB016284
Organism Additional Information Porphyromonas gingivalis is a Gram-negative anaerobic bacterium responsible for causing adult periodontal disease, a chronic inflammatory condition of the periodontal tissues. It is the source of a number of virulence factors that are thought to be important for deregulation of innate and inflammatory systems in the host.
Gene Information
Gene NameMfa1
NCBI Gene ID 6330018
Protein Information
Protein NameMfa1 (67 kDa minor fimbrillin)
UniProtKB/SwissProt ID O83017
NCBI RefSeq YP_001928403.1
EMBL-CDSBAA31954.1
UniProtKB Sequence >tr|O83017|O83017_PORGI 67kDa fimbrillin OS=Porphyromonas gingivalis GN=mfa1 PE=4 SV=1 MKLNKMFLVGALLSLGFASCSKEGNGPDPDNAAKSYMSMTLSMPMGSARAGDGQDQANPD YHYVGEWAGKDKIEKVSIYMVPQGGPGLVESAEDLDFGTYYENPTIDPATHNAILKPKKG IKVNSAVGKTVKVYVVLNDIAGKAKALLANVNAADFDAKFKEIIELSTQAQALGTVADGP NPATAAGKIAKKNGTTDETIMMTCLQPSDALTIEAAVSEANAIAGIKNQAKVTVERSVAR AMVSTKAQSYEIKATTQIGEIAAGSVLATITDIRWVVAQGERRQYLSKKRGTVPENTWVT PGSGFVPTSSTFHTNATEYYDYAGLWEDHNTNEAVISGTQVPTLADYQLQDVTGELANAL SGKFLLPNTHKSGANAASSDYKRGNTAYVLVRAKFTPKKEAFIDRGKTYSDNTAVPEYVA GEDFFVGENGQFYVSMKSVTDPKVGGVAGMKAHKYVKGKVLYYAWLNPSTTSPDSWWNSP VVRNNIYHIHIKSIKKLGFNWNPLVPDPDPSNPENPNNPDPNPDEPGTPVPTDPENPLPD QDTFMSVEVTVLPWKVHSYEVDL
Sequence length 563 AA
Subcellular LocationSurface
Function Minor fimbria of P. gingivalis intimately interacts with the SspB protein of Streptococcus gordonii.This interaction might aid in P. gingivalis colonization of plaque biofilm before it invades gingival tissue. The minor fimbria targets DC-SIGN on DCs for entry into DCs and that this targeting has the immunological consequence of dampening the immune response.
Glycosylation Status
Glycosylation Type Information currently not available with us.
Glycosite Sequence Logo
Technique(s) used for Glycosylation DetectionProQ staining
Glycan Information
Glycan Annotation The minor fimbria contain the DC-SIGN-targeting carbohydrates fucose (1.35 nmol/mg), mannose (2.68 nmol/mg), N-acetylglucosamine (2.27 nmol/mg), and N-acetylgalactosamine (0.652 nmol/mg).
Literature
Year of Identification2010
Year of Identification Month Wise2010.8
Reference1) Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. and Cutler, C.W. (2010) The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. J Bacteriol, 192, 4103-4110. [PubMed: 20562309]
Author Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. Cutler, C.W.
Research GroupDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-8703, USA.
Corresponding Author Cutler, C.W.
ContactDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-8703, USA.