ProGP485 (oprM efflux system outer membrane protein)

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ProGP ID ProGP485 (oprM efflux system outer membrane protein)
Validation Status Uncharacterized
Organism Information
Organism NameBurkholderia cenocepacia K56-2
Domain Bacteria
Classification Family: Burkholderiaceae
Order: Burkholderiales
Class: Betaproteobacteria
Division or phylum: "Proteobacteria"
Taxonomic ID (NCBI) 985075
Genome Information
GenBank NZ_LAUA01000000
EMBL LAUA01000000
Organism Additional Information Burkholderia cenocepacia causes opportunistic infections in plants, insects, animals and humans. It acts as a health threat to cystic fibrosis patients, causing lethal necrotizing pneumonia in some cases.
Gene Information
Gene Namebcal2820
Protein Information
Protein NameoprM efflux system outer membrane protein
UniProtKB/SwissProt ID B4EA04
NCBI RefSeq WP_012492848.1
EMBL-CDSCAR53120.1
UniProtKB Sequence >tr|B4EA04|B4EA04_BURCJ Efflux system outer membrane protein OS=Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) GN=oprM PE=3 SV=1 MMQKHALTAIAVALFATGCTMAPHYKRPDAPVAQAYPASGVYATQPGAAGARSANGQAAT AIGWREFFVDPRLQRLIEIALKNNRDLRVSVLNIEAARAQYQITRAGLFPTLDGTGTGNR QRLPNSLTAVPGRNITTTYNVGLSASWELDLFGRVQSLKDQALAQYLSTSYARQASEISL VSQVADQYLTLLSTDDLLKVTEDTLKTAQASYDLTKLQFDNGTGSELELRQAQTVVETAL ANQQAQARARAQALNALVLLIGEPLPDDLPAGMPLDAQNLLTDVPAGLPSDLLTRRPDVM QAEQTLLAANANIGAARAAFFPKISLTGAFGTASPTLGGLFKAGTAAWSFAPSIALPIFE GGQNIANLDLANVQKRIEIANYEKAIQSAFREVSDGLAARGTYDQQIAALERNEHAQQRR FDLSDLRYKNGVDSYLSVLTAQTDLYAAQQSLISARLARWTNLVDLYRALGGGWIQRAGE TPRAPDAPVDYDKAAAPAPASATATNG
Sequence length 507 AA
Subcellular LocationOuter membrane
Function Predicted NodT-like lipoprotein involved in efflux.
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Technique(s) used for Glycosylation DetectionZIC-HILIC,immunoblotting,tryptic digestion, and MS/MS analysis
Glycan Information
Glycan Annotation Trisaccharide HexNAc-HexNAc-Hex.
Protein Glycosylation linked (PGL) gene(s)
OST Gene NamePglLBC
OST ProGT IDProGT71 (PglLBc)
Literature
ReferenceLithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ. (2014) A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence. Mol Microbiol., 92(1):116-37. [PubMed: 24673753]
AuthorLithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ.
Research GroupDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada,
Corresponding Author Dennis JJ.
ContactDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada,