ProGP57

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ProGP ID ProGP57
Validation Status Uncharacterized
Organism Information
Organism NameMycobacterium tuberculosis H37Rv
Domain Bacteria
Classification Family: Mycobacteriaceae
Suborder: Corynebacterineae
Order: Actinomycetales
Subclass: Actinobacteridae
Class: Actinobacteria
Division or phylum: "Actinobacteria"
Taxonomic ID (NCBI) 1773
Genome Sequence(s)
GenBank BX842578.1
EMBL BX842578
Organism Additional Information It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens.
Protein Information
Protein Name38 kDa antigen
Function It is a disease associated species-specific antigen that displays high immunogenicity at B- and T-cell levels. Two epitopes namely a carbohydrate-dependent and a carbohydrate-independent, have been identified on this antigen using TB71 and TB72 monoclonal antibodies. Owing to its highly specific recognition of patients with lung tuberculosis and its nonreactivity with normal sera, it has a great potential for the serological diagnosis of tuberculosis.
Glycosylation Status
Technique(s) used for Glycosylation DetectionSchiff's reagent staining, peroxidase-conjugated concanavalin A (ConA)-binding
Glycan Information
Glycan Annotation 25.7% carbohydrate estimated by phenol-sulfuric acid assay.
Literature
Year of Identification1989
Year of Identification Month Wise1989.12
ReferenceRosales-Borjas, D.M., Zambrano-Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. and Ortiz-Ortiz, L. (1998) Rapid screening test for tuberculosis using a 38-kDa antigen from Mycobacterium tuberculosis. J Clin Lab Anal, 12, 126-129. [PubMed: 9524298]
Author Rosales-Borjas, D.M., Zambrano-Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. Ortiz-Ortiz, L.
Research GroupMiguel Oraá University Hospital, Guanare, Edo. Portuguesa, Venezuela.
Corresponding Author Ortiz-Ortiz, L.
ContactMiguel Oraá University Hospital, Guanare, Edo. Portuguesa, Venezuela.
ReferenceEspitia, C. and Mancilla, R. (1989) Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol, 77, 378-383. [PubMed: 2478323]
AuthorEspitia, C. Mancilla, R.
Research GroupDepartment of Immunology, National Autonomous University of Mexico,
Corresponding Author Mancilla, R.
ContactDepartment of Immunology, National Autonomous University of Mexico,