Latest update: September 24, 2018


ProGT16.4 (AglK)

Home -> ProGTdb -> Search ProGT_Accessory -> Display data

ProGT ID ProGT16.4 (AglK)
ProGT Pathway
Organism Information
Organism NameMethanococcus voltae PS
Domain Archaebacteria
Phylum Euryarchaeota
ClassificationFamily: Methanococcaceae
Order: Methanococcales
Class: Methanococci or Methanothermea
Division or phylum: "Euryarchaeota"
Taxonomic ID (NCBI)2188
Genome Information
Gene BankDQ372941
EMBLDQ372941
Gene Information
Gene NameaglK 
NCBI Reference SequenceDQ372941
Protein information
Protein NameAglK 
UniProtKB/ SwissProt IDB3VA58
UniProtKB Sequence>sp|B3VA58|AGLK_METVO UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase OS=Methanococcus voltae GN=aglK PE=1 SV=1 MADKLIYLIIPAYNEEKMIKNVVNNLQNHNYDNIIIVDDGSKDNTYKIMKELEEESKQNN NNNNNNNNNKVIAIKHEQNKGVGGATITGLKKAYELGADIAVTFDADGQHAPDDIAKVIQ PIINDSKEYVVGSRIKNPKEFKNMPLTKKVGNLGLSFITFLLGGYYVTDSQSGLRAFSKS ALKVLSEQLRAKRYETCSEALIIAKKNKLNIGEVPIKTIYTEYSMARGTNVMIGFKIFYR LLMLKMGKVLD
EMBL CDSACE74694.1.
Sequence length251 AA
Subcellular LocationMembrane (Integral component of membrane)
Glycosylation Information
CAZY FamilyGT2
EC Number (BRENDA)2.4.1.153
Sugar Donor SpecificityUDP-GlcNAc 
Acceptor Substrate SpecificityDol-P
Experimental ValidationIn vivo
ProductDol-P-GlcNAc
Donor SpecificityUDP-GlcNAc
Function in Glycosylation pathway1) AglK is responsible for the transfer of GlcNAc to the membrane-bound acceptor Dol-P.
Litrature
Year Of Validation2009 
Reference Chaban, B., Logan, S. M., Kelly, J. F., & Jarrell, K. F. (2009). AglC and AglK are involved in biosynthesis and attachment of diacetylated glucuronic acid to the N-glycan in Methanococcus voltae. Journal of bacteriology, 191(1), 187-195.

Authors Chaban, B., Logan, S. M., Kelly, J. F., & Jarrell, K. F.
Research groupsDepartment of Microbiology and Immunology, Queens University, Kingston, Ontario, K7L 3N6, Canada.
Corresponding Author Jarrell, K. F.
ContactsDepartment of Microbiology and Immunology, Queens University, Kingston, Ontario, K7L 3N6, Canada.
Reference Larkin, A., Chang, M. M., Whitworth, G. E., & Imperiali, B. (2013). Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis. Nature chemical biology, 9(6), 367.

Authors Larkin, A., Chang, M. M., Whitworth, G. E., & Imperiali, B.
Research groupsDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Corresponding Author Jarrell, K. F.
ContactsDepartment of Life Sciences, Ben Gurion University of the Negev, Beersheva, Israel.