Latest update: September 24, 2018


ProGT75.7 (GlyG)

Home -> ProGTdb -> Search ProGT_Accessory -> Display data

ProGT ID ProGT75.7 (GlyG)
ProGT Pathway
Organism Information
Organism NameStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Domain Bacteria
PhylumFirmicutes
ClassificationFamily: Streptococcaceae
Order: Lactobacillales
Class: Bacilli (or Firmibacteria)
Division or phylum: "Firmicutes"
Taxonomic ID (NCBI)170187
Genome Information
Gene BankAE005672
EMBLAE005672
Gene Information
Gene NameglyG (SP_1764)  
Protein information
Protein NameGlyG  
UniProtKB/ SwissProt IDA0A0H2UR96
NCBI Ref SeqWP_001292326.1
UniProtKB Sequence>tr|A0A0H2UR96|A0A0H2UR96_STRPN Glycosyl transferase, family 2 OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_1764 PE=4 SV=1 MSELISVVVPIYNTGKYLVECVEHILKQTYQNIEIILVDDGSTDNSGEICDAFMMQDNRV RVLHQENKGGAAQAKNMGISVAKGEYITIVDSDDIVKENMIETLYQQVQEKDADVVIGNY YNYDESDGNFYFYVTGQDFCVEELAIQEIMNRQAGDWKFNSSAFILPTFKLIKKELFNEV HFSNGRRFDDEATMHRFYLLASKIVFINDNLYLYRRRSGSIMRTEFDLSWARDIVEVFSK KISDCVLAGLDVSVLRIRFVNLLKDYKQTLEYHQLTDTEEYKDICFRLKLFFDAEQRNGK S
EMBL CDSAAK75839
Sequence length301 AA
Glycosylation Information
Sugar Donor SpecificityUDP-Glc 
Acceptor Substrate SpecificitySRR1-GlcNAc-Glc
Experimental ValidationIn vivo and In vitro
ProductSRR1-GlcNAc-Glc-Glc
Donor SpecificityUDP-Glc
Function in Glycosylation pathway1) GlyG also responsible for the third-step glycosylation, it transfers UDP-glc on acceptor SRR1-GlcNAc-Glc to form acceptor SRR1-GlcNAc-Glc-Glc.
Additional Information1) GlyG has significantly higher activity toward UDP-Glc.  
Litrature
Year Of Validation2017 
Reference Jiang, Y. L., Jin, H., Yang, H. B., Zhao, R. L., Wang, S., Chen, Y., & Zhou, C. Z. (2017). Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. The Journal of Biological Chemistry, 292, 6213-6224.

Authors Jiang, Y. L., Jin, H., Yang, H. B., Zhao, R. L., Wang, S., Chen, Y., & Zhou, C. Z.
Research groups1 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China. 2 Key Laboratory of Structural Biology, Chinese Academy of Science, Hefei, Anhui 230027, China. 3 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China. 4 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Corresponding AuthorZhou, C. Z.
Contacts1 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China.