Latest update: September 24, 2018


ProGT39 (HMW1C)

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ProGT ID ProGT39 (HMW1C)
ProGT Pathway
Organism Information
Organism NameHaemophilus influenzae strain Rd
Clinical ImplicationPathogenic
DomainBacteria
PhylumProteobacteria
ClassificationFamily: Pasteurellaceae
Order: Pasteurellales
Class: Gammaproteobacteria
Division or phylum: "Proteobacteria"
Taxonomic ID (NCBI)71421
Genome Information
Gene BankNC_000907.1
Gene Information
Gene Namehmw1c
Protein information
Protein NameHMW1C 
Subcellular LocationCytoplasm
Function in Native Organism 1) It transfers the galactose and glucose to the native adhesion protein HMW1 (HMW1802?1406).
Additional Information1) Glycosylation is essential for HMW1 stability as well as for optimal HMW1 tethering to the bacterial surface, which ultimately required for HMW1-mediated adherence.
Glycosyltransferase Information
Glycosylation TypeN- (Asn) linked 
CAZY FamilyGT41
EC Number (BRENDA)2.4.1.-
Mechanism of Glycan TransferSequential
Acceptor specificity Sequon_1Asn-Xaa-Ser
Donor TypeNucleotide activated sugars
Donor SpecificityUDP-Glc and UDP-Gal
Glycan Information
Glycan transferredMonosaccharides (Glc and Gal) 
Method of Glycan IndentificationDIG Glycan Kit, and GC/MS
Experimental_strategiesIn vitro and In vivo  
Acceptor Subtrate Information
Acceptor Substrate name HMW1 (HMW1802–1406)
ProGPdb ID ProGP227
Litrature
Year Of Validation2010 
Reference Grass, S., Lichti, C. F., Townsend, R. R., Gross, J., & Geme III, J. W. S. (2010). The Haemophilus influenzae HMW1C protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin. PLoS pathogens, 6(5), e1000919.

Authors Grass, S., Lichti, C. F., Townsend, R. R., Gross, J., & Geme III, J. W. S.
Research groupsDepartment of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America.
Corresponding Author Geme III, J. W. S.
ContactsDepartment of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America.