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ProGT7 (TcsL 9048)

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ProGT ID ProGT7 (TcsL 9048)
Organism Information
Organism NameClostridium sordellii VPI 9048
Clinical ImplicationPathogenic
DomainBacteria
PhylumFirmicutes
ClassificationFamily: Clostridiaceae
Order: Clostridiales
Class: Clostridia
Phylum: Firmicutes
Taxonomic ID (NCBI)1505
Genome Information
Gene BankNZ_AQGJ01000159.1
Gene Information
Gene NametcsL
Protein information
Protein NameTcsL9048 
UniProtKB/ SwissProt IDV5T923
UniProtKB Sequence>tr|V5T923|V5T923_PAESO Cytotoxin L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=4 SV=1 MSLVNKAQLQKMAYVKFRIQEDEYVAILNALEEYHNMSESSVVEKYLKLKDINNLTDNYL NTYKKSGRNKALKKFKEYLTMEVLELKNNSLTPVEKNLHFIWIGGQINDTAINYINQWKD VNSDYTVKVFYDSNAFLINTLKKTIVESATNNTLESFRENLNDPEFDYNKFYRKRMEIIY DKQKHFIDYYKSQIEENPEFIIDNIIKTYLSNEYSKDLEALNKYIEESLNKITANNGNDI RNLEKFADEDLVRLYNQELVERWNLAAASDILRISMLKEDGGVYLDVDMLPGIQPDLFKS INKPDSITDTSWEMIKLEAIMKYKEYIPGYTSKNFDMLDEEVQSSFESALSSTSDKSEIF LPLDDIKVSPLEVKIAFANNSVINQALISLKDSYGSDLVISQIKNRYKILNDNLNPAINE GNDFNTTMKTFNDNLVSISNEDNIMFMIKIADYLKVGFAPDVRSTINLSGPGVYTGAYQD LLMFKDNSINIHLLEPELRNFEFPKTKISQLTEQEITSLWSFNQARAKSQFEEYKKGYFE GALGEDDILDFSQNTVLDKDYVVEKISSSMRTPNKEYVHYIVQLQGDNVSYEAACNLFAK NPYYNILFQKNIENSETAYYYNLIYNKLQEIDKYRIPNLISNRHKIKLTFIGHGKSEFNT DTFANLDVNSLSSEIETILNLAKEDISPKSIEINLLGCNMFSYNVNVEETYPGKLLLKIK DIVSKLMPSISQDSITVSANQYEVRINKEGRRELLDHSGKWINKEESIIKDISSKEYISF NPKENKIIVKSKNLHELSTLLQEIKNNSNSSDIDLEKKVMLTECEINVASNIDTQIVEER IEEAKNLTSDSINYIKNEFKLIESISDALYDLKHQNGLDDSHFISFEDISKTENGFRIRF INKETGNSIFIETEKEIFSEYAAHISKEISNIKDTIFDNVNGKLVKKVNLDAAHEVNTLN SAFFIQSLIEYNTTKESLSNLSVAMKVQVYAQLFSTGLNTITDASKVVELVSTALDETID LLPTLSEGLPIIATIIDGVSLGAAIKELSETNDPLLRQEIEAKIGIMAVNLTAASTAIVT SALGIASGFSILLVPLAGISAGIPSLVNNELILQDKATKVIDYFKHISLAETEGAFTLLD DKIIMPQDDLVLSEIDFNNNSITLGKCEIWRTEGGSGHTFTDDIDHFFSSPSITYRKPWL SIYDVLNIKKEKIDFSKDLMVLPNAPNRVFSYEMGWTPGFRSLDNDGTKLLDRIRDHYEG QFYWRYFAFIADALITKLKPRYEDTNVRINLDGNTRSFIVPVITTEQIRKNLSYSFYGSG GSYSLSLSPYNMNIDLNLVENDTWVIDVDNVVKNITIESDEIQKGELIENILSKLNIEDN KIVLNNHTINFYGAINESNRFISLTFSILEDINIIIEIDLVSKSYKILLSGNCIKLIENS SDIQQKIDHIGFNGEHQKYIPYSYIDNETKYNGFIDYSKKEGLFTAEFSNESIIRNIYMP DSNNLFIYSSKDLKDIRIINKGDVKLLIGNYFKDNMKVSLSFTIEDTNTIKLNGVYLDEN GVAQILKFMNNAKSALNTSNSLMNFLESINIKNIFYNNLDPNIKFILDTNFIISGSNSIG QFELICDKDKNIQPYFIKFKIKETSYTLYAGNRQNLIVEPSYHLDDSGNISSTVINFSQK YLYGIDRYVNKVIITPNLYTDEINITPVYKPNYICPEVIILDANYINEKINININDLSIR YVWDNDGSDLILIANSEEDNQPQVKIRFVNVFKSDTAADKLSFNFSDKQDVSVSKIISTF SLAAYSDGVFDYEFGLVSLDNECFYINSFGNMVSGLIYINDSLYYFKPPKNNLITGFTTI DDNKYYFDPTKSGAASIGEITIDGKDYYFNKQGILQVGVINTSDGLKYFAPAGTLDENLE GESVNFIGKLNIDGKIYYFEDNYRAAVEWKSLDGETYYFNPKTGEALKGLHQIGDNKYYF DNNGIMQTGFITINDKVFYFNNDGVMQVGYIEVNGKYFYFGKNGERQLGVFNTPDGFKFF GPKDDDLGTEEGELTLYNGILNFNGKIYFFDISNTAVVGWGILDDGSTYYFDDNTAEACI GLTVINDCKYYFDDNGIRQLGFITINDNIFYFSESGKIELGYQNINGNYFYIDESGLVLI GVFDTPDGYKYFAPLNTVNDNIYGQAVEYSGLVRLNEDVYYFGETYKIETGWIENETDKY YFDPETKKAYKGINVVDDIKYYFDENGIMKTGLISFENNNYYFNEDGKMQFGYLNIKDKM FYFGKDGKMQIGVFNTPDGFKYFAHQNTLDENFEGESINYTGWLDLDGKRYYFTDEYIAA TSSLTIDGYNYYFDPDTAELVVSE
EMBL CDSAHB59887.1
Sequence length2364 AA
Additional Information1) rN-TcsL-9048 and full length TcsL-9048 glucosylate both Rho- and Ras-GTPases.
Glycosyltransferase Information
Glycosylation TypeO- (Ser/Thr) linked 
Mechanism of Glycan TransferSequential
Donor TypeNucleotide activated sugars
Donor SpecificityUDP-Glc and UDP-GlcNAc
Glycan Information
Glycan transferredMonosaccharids (Glc and GlcNAc) 
Experimental_strategiesIn vitro 
Litrature
Year Of Validation1996 
Reference Hofmann, F., Rex, G., Aktories, K., & Just, I. (1996). The Ras-Related Protein Ral Is Monoglucosylated byClostridium sordelliiLethal Toxin. Biochemical and biophysical research communications, 227(1), 77-81.

Authors Hofmann, F., Rex, G., Aktories, K., & Just, I.
Research groupsInstitute of Pharmacology and Toxicology, Albert-Ludwigs-Universität Freiburg, Germany
Corresponding Author Just, I.
ContactsInstitute of Pharmacology and Toxicology, Albert-Ludwigs-Universität Freiburg, Germany
Reference Genth, H., Pauillac, S., Schelle, I., Bouvet, P., Bouchier, C., Varela?Chavez, C., Just, I. & Popoff, M. R. (2014). Haemorrhagic toxin and lethal toxin from C lostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins. Cellular microbiology, 16(11), 1706-1721.

Authors Genth, H., Pauillac, S., Schelle, I., Bouvet, P., Bouchier, C., Varela?Chavez, C., Just, I. & Popoff, M. R.
Research groupsInstitute of Toxicology, Medical School Hannover, Hannover, Germany.
Corresponding Author Popoff, M. R.
ContactsInstitute of Toxicology, Medical School Hannover, Hannover, Germany.