Latest update: September 24, 2018


ProGT81 (TcnA)

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ProGT ID ProGT81 (TcnA)
Organism Information
Organism NameClostridium novyi 590
Clinical ImplicationPathogenic
DomainBacteria
PhylumFirmicutes
ClassificationFamily: Clostridiaceae
Order: Clostridiales
Class: Clostridia
Phylum: Firmicutes
Taxonomic ID (NCBI)1542
Genome Information
Gene Information
Gene NametcnA
Protein information
Protein NameTcnA 
UniProtKB/ SwissProt IDQ46149
Glycosyltransferase Information
Glycosylation TypeO- (Ser/Thr) linked 
Mechanism of Glycan TransferSequential
Donor TypeNucleotide activated sugars
Donor SpecificityUDP-GlcNAc
Glycan Information
Glycan transferredMonosaccharid (GlcNAc) 
Experimental_strategiesIn vitro 
Acceptor Subtrate Information
Acceptor Substrate name Rac1
Acceptor Substrate name RhoA
Acceptor Substrate name RhoB
Litrature
Year Of Validation2014 
Reference Genth, H., Pauillac, S., Schelle, I., Bouvet, P., Bouchier, C., Varela?Chavez, C., Just, I. & Popoff, M. R. (2014). Haemorrhagic toxin and lethal toxin from C lostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins. Cellular microbiology, 16(11), 1706-1721.

Authors Genth, H., Pauillac, S., Schelle, I., Bouvet, P., Bouchier, C., Varela?Chavez, C., Just, I. & Popoff, M. R.
Research groupsInstitute of Toxicology, Medical School Hannover, Hannover, Germany.
Corresponding Author Popoff, M. R.
ContactsInstitute of Toxicology, Medical School Hannover, Hannover, Germany.