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ProGlyProt ID
BU227
Organism Information
Organism Name
Mycobacterium tuberculosis H37Rv
Domain
Bacteria
Classification
Family: Mycobacteriaceae
Suborder: Corynebacterineae
Order: Actinomycetales
Subclass: Actinobacteridae
Class: Actinobacteria
Division or phylum: "Actinobacteria"
 
 
Protein Information
Protein Name
38 kDa antigen
Function
It is a disease associated species-specific antigen that displays high immunogenicity at B- and T-cell levels. Two epitopes namely a carbohydrate-dependent and a carbohydrate-independent, have been identified on this antigen using TB71 and TB72 monoclonal antibodies. Owing to its highly specific recognition of patients with lung tuberculosis and its nonreactivity with normal sera, it has a great potential for the serological diagnosis of tuberculosis.
 
 
Glycosylation Status
Glycosylation Type
Information currently not available with us.
Technique(s) used for Glycosylation Detection
Schiff's reagent staining, peroxidase-conjugated concanavalin A (ConA)-binding
 
 
Glycan Information
Glycan Annotation
25.7% carbohydrate estimated by phenol-sulfuric acid assay.
 
 
Literature
Reference(s)
1) Rosales-Borjas, D.M., Zambrano-Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. and Ortiz-Ortiz, L. (1998) Rapid screening test for tuberculosis using a 38-kDa antigen from Mycobacterium tuberculosis. J Clin Lab Anal, 12, 126-129. [PubMed: 9524298]
2) Espitia, C. and Mancilla, R. (1989) Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol, 77, 378-383. [PubMed: 2478323]
Year of Identification
1989
 
 
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