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ProGlyProt ID
BU245
Organism Information
Organism Name
Porphyromonas (Bacteroides) gingivalis
Domain
Bacteria
Classification
Family: "Porphyromonadaceae"
Order: "Bacteroidales"
Class: "Bacteroidia"
Division or phylum: "Bacteroidetes"
Taxonomic ID (NCBI)
 
 
Genome Sequence(s)
GenBank
EMBL
Organism Additional Information
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium responsible for causing adult periodontal disease, a chronic inflammatory condition of the periodontal tissues. It is the source of a number of virulence factors that are thought to be important for deregulation of innate and inflammatory systems in the host.
 
 
Gene Information
Gene Name
Mfa1
NCBI Gene ID
 
 
Protein Information
Protein Name
Mfa1 (67 kDa minor fimbrillin)
UniProtKB/SwissProt ID
NCBI RefSeq
EMBL-CDS
UniProtKB Sequence
Sequence length
563 AA
Subcellular Location
Surface
Function
Minor fimbria of P. gingivalis intimately interact with the SspB protein of Streptococcus gordonii.This interaction might aid in P. gingivalis colonization of plaque biofilm before it invades gingival tissue. The minor fimbria target DC-SIGN on DCs for entry into DCs and that this targeting has the immunological consequence of dampening the immune response.
 
 
Glycosylation Status
Glycosylation Type
Information currently not available with us.
Technique(s) used for Glycosylation Detection
ProQ staining
 
 
Glycan Information
Glycan Annotation
The minor fimbria contain the DC-SIGN-targeting carbohydrates fucose (1.35 nmol/mg), mannose (2.68 nmol/mg), N-acetylglucosamine (2.27 nmol/mg), and N-acetylgalactosamine (0.652 nmol/mg).
 
 
Literature
Reference(s)
1) Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. and Cutler, C.W. (2010) The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. J Bacteriol, 192, 4103-4110. [PubMed: 20562309]
Year of Identification
2010
 
 
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