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ProGlyProt ID
BU267
Organism Information
Organism Name
Streptococcus pyogenes type M5 (Manfredo strain)
Domain
Bacteria
Classification
Family: Streptococcaceae
Order: Lactobacillales
Class: Bacilli (or Firmibacteria)
Division or phylum: "Firmicutes"
Taxonomic ID (NCBI)
 
 
Genome Sequence(s)
GenBank
EMBL
 
 
Gene Information
Gene Name
sagP or arcA (SpyM50577)
NCBI Gene ID
 
 
Protein Information
Protein Name
Streptococcal acid glycoprotein SAGP
UniProtKB/SwissProt ID
NCBI RefSeq
EMBL-CDS
UniProtKB Sequence
Sequence length
411 AA
Subcellular Location
Intracellular
Function
SAGP,or its homolog,possesses AD (L-arginine deiminase) activity. The potent inhibition of proliferation of human T-cells by streptococcal CE is due to activity of this enzyme.
 
 
Literature
Reference(s)
1) Degnan, B.A., Fontaine, M.C., Doebereiner, A.H., Lee, J.J., Mastroeni, P., Dougan, G., Goodacre, J.A. and Kehoe, M.A. (2000) Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect Immun, 68, 2441-2448. [PubMed: 10768929]
2) Degnan, B.A., Palmer, J.M., Robson, T., Jones, C.E., Fischer, M., Glanville, M., Mellor, G.D., Diamond, A.G., Kehoe, M.A. and Goodacre, J.A. (1998) Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infect Immun, 66, 3050-3058. [PubMed: 9632565]
Year of Identification
2000
 
 
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