ProGP1302 (NagC)
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| ProGP ID | ProGP1302 (NagC) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Salmonella enterica |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : Gammaproteobacteria Orders : Enterobacterales Family : Enterobacteraceae Genus : Salmonella Species : enterica |
| Taxonomic ID (NCBI) | 28901 |
| Genome Information | |
| GenBank | CP003278.1 |
| Organism Additional Information | It coordinates amino-sugar metabolism in bacteria, hence enchances DNA binding activity. Overall it helps in the cell wall synthesis and glycosylation of other bacterial or host proteins. SseK1 glycosylation adds another layer of gene regulation to this pathogen, allowing for fine-tuning of gene expression in response to bacterial needs. |
| Gene Information | |
| NCBI Gene ID | CP003278 |
| Protein Information | |
| Protein Name | NagC |
| UniProtKB/SwissProt ID | A0A0W4GRC9 |
| NCBI RefSeq | UTL66876.1 |
| UniProtKB Sequence | >tr|A0A0W4GRC9|A0A0W4GRC9_SALER DNA-binding transcriptional regulator NagC OS=Salmonella enterica OX=28901 GN=nagC PE=3 SV=1 MTPGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERG LIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDTTLTLYDLSSKVVAEEHYPLPER TQETLEHALLNTIAVFIDSCQRKIRELIAISVILPGLVDPESGVIRYMPHIQVENWGLVE ALEKRFHVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTI CKAANRGDSLASEVIEHVGRHLGKTIAIAINLFNPQKIVIAGEIIEADKVLLPAIESCIN TQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQCLLES |
| Function | Motility |
| Glycosylation Status | |
| Glycosylation Type | N- (Arg) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | R25, R35, R54 |
| Technique(s) used for Glycosylation Detection | Western blotting, MS |
| Glycan Information | |
| Glycan Annotation | Monosaccharide (GlcNAc) |
| Technique(s) used for Glycan Identification | MS |
| Protein Glycosylation linked (PGL) gene(s) | |
| OST ProGT ID | ProGT148 |
| Literature | |
| Year of Identification | 2022 |
| Reference | El Qaidi, S., Scott, N.E., Hays, M.P. and Hardwidge, P.R., 2022. Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica. Scientific Reports, 12(1), pp.1-13. |
| Corresponding Author | Philip R. Hardwidge |
| Contact | College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA |