ProGP176 (TibA (outer membrane protein synthesized as preTibA))
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| ProGP ID | ProGP176 (TibA (outer membrane protein synthesized as preTibA)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Escherichia coli (ETEC) strain H10407 |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : gammaproteobacteria Orders : Enterobacterales Family : Enterobacteriaceae Genus : Escherichia Species : coli Strain : H10407 |
| Taxonomic ID (NCBI) | 316401 |
| Genome Information | |
| GenBank | FN649414 |
| EMBL | FN649414 |
| Organism Additional Information | Escherichia coli (Gram-negative) is the predominant facultative organism in the human intestine. It is responsible for a number of diseases like urinary tract infections, gastroenteritis (diarrhoea), meningitis, traveler's diarrhea and hemorrhagic colitis. There are a myriad of serotypes of pathogenic E. coli. Adhesion to the host cells is an important step in its pathogenesis. However, most strains are harmless and normal flora residing in the gut. |
| Gene Information | |
| Gene Name | tibA (ETEC_2141) |
| Protein Information | |
| Protein Name | TibA (outer membrane protein synthesized as preTibA) |
| UniProtKB/SwissProt ID | Q9XD84 |
| EMBL-CDS | CBJ01643.1 |
| UniProtKB Sequence | >sp|Q9XD84|TIBA_ECOLX Adhesin/invasin TibA autotransporter OS=Escherichia coli GN=tibA PE=1 SV=1 MNKVYNTVWNESTGTWVVTSELTRKGGLRPRQIKRTVLAGLIAGLLMPSMPALAAAYDNQ TIGRGETSKSMHLSAGDTAKNTTINSGGKQYVSSGGSATSTTINIGGVQHVSSGGSATSS TINSGGHQHVSSGGSATNTTVNNGGRQTVFSGGSAMGTIINSGGDQYVISGGSATSASVT SGARQFVSSGGIVKATSVNSGGRQYVRDGGSATDTVLNNTGRQFVSSGGSAAKTTINSGG GMYLYGGSATGTSIYNGGRQYVSSGGSATNTTVYSGGRQHVYIDGNVTETTITSGGMLQV EAGGSASKVIQNSGGAVITNTSAAVSGTNDNGSFSIAGGSAVNMLLENGGYLTVFDGHQA SDTMVGSDGTLDVRSGGVLYGTTTLTDKGALVGDVVTNEGNLYYLNNSTATFTGTLTGTG TLTQEGGNTRFSGLLSQDGGIFLQSGGAMTMDALQAKANVTTQSGTTLTLDNGTILTGNV AGDSTGAGDMAVKGASVWHLDGDSTVGALTLDNGTVDFRPSTTTRMTPAFQAVSLALGSL SGSGTFQMNTDIASHTGDMLNVAGNASGNFVLDIKNTGLEPVSAGAPLQVVQTGGGDAAF TLKGGKVDAGTWEYGLSKENTNWYLKADTPPPVTPPTNPDADNPDAGNPDAGNPDAGNPD AGNPDAGKPGTGKPDAGTSSSPVRRTTKSVDAVLGMATAPAYVFNSELDNLRFRHGDVMQ NTRAPGGVWGRYTGSDNRISGGASSGYTLTQNGFETGADMVFDLSDSSLAVGTFFSYSDN SIKHARGGKSNVDSSGGGLYATWFDNDGYYVDGVLKYNRFNNELRTWMSDGTAVKGDYSQ NGFGGSLEAGRTFSLNENAWAQPYVRTTAFRADKKEIRLNNGMKASIGATKSLQAEAGLK LGMTLDVAGKEVKPYLSAAVSHEFSDNNKVRINDTYDFRNDISGTTGKYGLGVNAQLTPN AGVWAEARYENGKQTESPITGGVGFRINF |
| Sequence length | 989 AA |
| Subcellular Location | Secreted (surface associated) |
| Function | Adhesion-invasion protein of enterotoxigenic E. coli. Secreted as autotransporter, which represents a branch of the type V secretion pathway. Mediates bacterial autoaggregation and biofilm formation as well as adhesion to and invasion of mammalian cells. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Oxidation of the glycans with periodate and labeling with hydrazide-conjugated digoxigenin (DIG). |
| Glycan Information | |
| Glycan Annotation | 6-deoxy-Tal-Thr. Multiple heptoses. |
| Literature | |
| Year of Identification | 1999 |
| Year of Identification Month Wise | 1999.8 |
| Reference | Lindenthal, C. and Elsinghorst, E.A., 1999. Identification of a glycoprotein produced by enterotoxigenic Escherichia coli. Infection and immunity, 67(8), pp.4084-4091. |
| Corresponding Author | Eric A. Elsinghorst |
| Contact | Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045-2106, USA. |