ProGP263 (Rv3491)
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| ProGP ID | ProGP263 (Rv3491) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis |
| Domain | Bacteria |
| Classification | Family: Mycobacteriaceae Suborder: Corynebacterineae Order: Actinomycetales Subclass: Actinobacteridae Class: Actinobacteria Division or phylum: "Actinobacteria" |
| Taxonomic ID (NCBI) | 1773 |
| Genome Information | |
| GenBank | BX842583.1 |
| EMBL | BX842583 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Gene Information | |
| Gene Name | (Rv3491) |
| NCBI Gene ID | 888382 |
| GenBank Gene Sequence | NC_000962.2 |
| Protein Information | |
| Protein Name | Rv3491 |
| UniProtKB/SwissProt ID | O06354 |
| NCBI RefSeq | NP_218008.1 |
| EMBL-CDS | CAB08714.1 |
| UniProtKB Sequence | >tr|O06354|O06354_MYCTU Putative uncharacterized protein OS=Mycobacterium tuberculosis GN=MT3595 PE=4 SV=1 MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQ PSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGRARMSSMLWTFQVNQAD GVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSKQPFSLQLIGPPPSPVQR YPLYCNNIAMCY |
| Sequence length | 192 AA |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | S176 |
| Glycosite(s) Annotated Protein Sequence | >tr|O06354|O06354_MYCTU Putative uncharacterized protein OS=Mycobacterium tuberculosis GN=MT3595 PE=4 SV=1 MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQ PSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGRARMSSMLWTFQVNQAD GVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSKQPFSLQLIGPPPS*(176)PVQR YPLYCNNIAMCY |
| Sequence Around Glycosites (21 AA) | FSLQLIGPPPSPVQRYPLYCN |
| Technique(s) used for Glycosylation Detection | Concanavalin A (ConA) binding |
| Literature | |
| Year of Identification | 2009 |
| Year of Identification Month Wise | 2009.02 |
| Reference | González-Zamorano M, Mendoza-Hernández G, Xolalpa W, Parada C, Vallecillo AJ, Bigi F, Espitia C (2009) .Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins.J Proteome Res. 2009, 8(2), 721-33. [PubMed: 19196185] |
| Author | Gonzalez-Zamorano, M., Mendoza-Hernandez, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C |
| Research Group | Department of Immunology, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico. |
| Corresponding Author | Espitia, C |
| Contact | Department of Immunology, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico. |
| Reference | Smith GT, Sweredoski MJ, Hess S.(2014) O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. J Proteomics, 97, 296-306. [PubMed: 23702328] |
| Author | Smith GT, Sweredoski MJ, Hess S. |
| Research Group | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA. |
| Corresponding Author | Hess S. |
| Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA. |