ProGP345 (Mfa1 (67 kDa minor fimbrillin))
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| ProGP ID | ProGP345 (Mfa1 (67 kDa minor fimbrillin)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Porphyromonas gingivalis |
| Domain | Bacteria |
| Classification | Family: "Porphyromonadaceae" Order: "Bacteroidales" Class: "Bacteroidia" Division or phylum: "Bacteroidetes" |
| Taxonomic ID (NCBI) | 837 |
| Genome Information | |
| GenBank | AP009380.1 |
| EMBL | AB016284 |
| Organism Additional Information | Porphyromonas gingivalis is a Gram-negative anaerobic bacterium responsible for causing adult periodontal disease, a chronic inflammatory condition of the periodontal tissues. It is the source of a number of virulence factors that are thought to be important for deregulation of innate and inflammatory systems in the host. |
| Gene Information | |
| Gene Name | Mfa1 |
| NCBI Gene ID | 6330018 |
| GenBank Gene Sequence | NC_010729 |
| Protein Information | |
| Protein Name | Mfa1 (67 kDa minor fimbrillin) |
| UniProtKB/SwissProt ID | O83017 |
| NCBI RefSeq | YP_001928403.1 |
| EMBL-CDS | BAA31954.1 |
| UniProtKB Sequence | >tr|O83017|O83017_PORGI 67kDa fimbrillin OS=Porphyromonas gingivalis GN=mfa1 PE=4 SV=1 MKLNKMFLVGALLSLGFASCSKEGNGPDPDNAAKSYMSMTLSMPMGSARAGDGQDQANPD YHYVGEWAGKDKIEKVSIYMVPQGGPGLVESAEDLDFGTYYENPTIDPATHNAILKPKKG IKVNSAVGKTVKVYVVLNDIAGKAKALLANVNAADFDAKFKEIIELSTQAQALGTVADGP NPATAAGKIAKKNGTTDETIMMTCLQPSDALTIEAAVSEANAIAGIKNQAKVTVERSVAR AMVSTKAQSYEIKATTQIGEIAAGSVLATITDIRWVVAQGERRQYLSKKRGTVPENTWVT PGSGFVPTSSTFHTNATEYYDYAGLWEDHNTNEAVISGTQVPTLADYQLQDVTGELANAL SGKFLLPNTHKSGANAASSDYKRGNTAYVLVRAKFTPKKEAFIDRGKTYSDNTAVPEYVA GEDFFVGENGQFYVSMKSVTDPKVGGVAGMKAHKYVKGKVLYYAWLNPSTTSPDSWWNSP VVRNNIYHIHIKSIKKLGFNWNPLVPDPDPSNPENPNNPDPNPDEPGTPVPTDPENPLPD QDTFMSVEVTVLPWKVHSYEVDL |
| Sequence length | 563 AA |
| Subcellular Location | Surface |
| Function | Minor fimbria of P. gingivalis intimately interacts with the SspB protein of Streptococcus gordonii.This interaction might aid in P. gingivalis colonization of plaque biofilm before it invades gingival tissue. The minor fimbria targets DC-SIGN on DCs for entry into DCs and that this targeting has the immunological consequence of dampening the immune response. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | ProQ staining |
| Glycan Information | |
| Glycan Annotation | The minor fimbria contain the DC-SIGN-targeting carbohydrates fucose (1.35 nmol/mg), mannose (2.68 nmol/mg), N-acetylglucosamine (2.27 nmol/mg), and N-acetylgalactosamine (0.652 nmol/mg). |
| Literature | |
| Year of Identification | 2010 |
| Year of Identification Month Wise | 2010.8 |
| Reference | Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. and Cutler, C.W., 2010. The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. Journal of bacteriology, 192(16), pp.4103-4110. |
| Corresponding Author | Christopher W. Cutler |
| Contact | Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-8703, USA. |
| Reference | Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. and Cutler, C.W. (2010) The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. J Bacteriol, 192, 4103-4110. [PubMed: 20562309] |
| Author | Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. Cutler, C.W. |
| Research Group | Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-8703, USA. |
| Corresponding Author | Cutler, C.W. |
| Contact | Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-8703, USA. |