ProGP457 (LppO (Putative lipoprotein))
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| ProGP ID | ProGP457 (LppO (Putative lipoprotein)) | ||||||||||||||||||||||||
| Validation Status | Characterized | ||||||||||||||||||||||||
| Organism Information | |||||||||||||||||||||||||
| Organism Name | Mycobacterium tuberculosis H37Rv | ||||||||||||||||||||||||
| Domain | Bacteria | ||||||||||||||||||||||||
| Classification | Family: Mycobacteriaceae Suborder: Corynebacterineae Order: Actinomycetales Subclass: Actinobacteridae Class: Actinobacteria Division or phylum: "Actinobacteria" | ||||||||||||||||||||||||
| Taxonomic ID (NCBI) | 83332 | ||||||||||||||||||||||||
| Genome Information | |||||||||||||||||||||||||
| GenBank | NC_000963.3 | ||||||||||||||||||||||||
| EMBL | CP009480 | ||||||||||||||||||||||||
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. | ||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||
| Gene Name | lppO (Rv2290) | ||||||||||||||||||||||||
| NCBI Gene ID | 887203 | ||||||||||||||||||||||||
| GenBank Gene Sequence | NC_000962.3 | ||||||||||||||||||||||||
| Protein Information | |||||||||||||||||||||||||
| Protein Name | LppO (Putative lipoprotein) | ||||||||||||||||||||||||
| UniProtKB/SwissProt ID | P9WK71 | ||||||||||||||||||||||||
| NCBI RefSeq | NP_216806 | ||||||||||||||||||||||||
| EMBL-CDS | CCP45072.3 | ||||||||||||||||||||||||
| UniProtKB Sequence | >sp|P9WK71|LPPO_MYCTU Putative lipoprotein LppO OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=lppO PE=1 SV=1 MTDPRHTVRIAVGATALGVSALGATLPACSAHSGPGSPPSAPSAPAAATVMVEGHTHTIS GVVECRTSPAVRTATPSESGTQTTRVNAHDDSASVTLSLSDSTPPDVNGFGISLKIGSVD YQMPYQPVQSPTQVEATRQGKSYTLTGTGHAVIPGQTGMRELPFGVHVTCP | ||||||||||||||||||||||||
| Sequence length | 171AA | ||||||||||||||||||||||||
| Subcellular Location | Membrane | ||||||||||||||||||||||||
| Glycosylation Status | |||||||||||||||||||||||||
| Glycosylation Type | O- (Ser/Thr) linked | ||||||||||||||||||||||||
| Experimentally Validated Glycosite(s) in Full Length Protein | T73, T75, S77, S79, S81, T83 and S84 | ||||||||||||||||||||||||
| Glycosite(s) Annotated Protein Sequence | >sp|P9WK71|LPPO_MYCTU Putative lipoprotein LppO OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=lppO PE=1 SV=1 MTDPRHTVRIAVGATALGVSALGATLPACSAHSGPGSPPSAPSAPAAATVMVEGHTHTIS GVVECRTSPAVRT*(73)AT*(75)PS*(77)ES*(79)GT*(81)QT*(83)T*(84)RVNAHDDSASVTLSLSDSTPPDVNGFGISLKIGSVD YQMPYQPVQSPTQVEATRQGKSYTLTGTGHAVIPGQTGMRELPFGVHVTCP | ||||||||||||||||||||||||
| Sequence Around Glycosites (21 AA) | CRTSPAVRTATPSESGTQTTR
TSPAVRTATPSESGTQTTRVN PAVRTATPSESGTQTTRVNAH VRTATPSESGTQTTRVNAHDD TATPSESGTQTTRVNAHDDSA ATPSESGTQTTRVNAHDDSAS | ||||||||||||||||||||||||
| Average Amino Acid Composition around Glycosite(s) | _T(he)ATPSESGTQTTR__TAT(he)PSESGTQTTR__TATPS(he)ESGTQTTR_TATPS(he)ESGTQTTR__TATPS(he)ESGTQTTR_TATPS(he)ESGTQTTR__TAT(he)PSESGTQT(he)TR_ | ||||||||||||||||||||||||
| ProGP Web Logo |  Technique(s) used for Glycosylation Detection | HCD, ETD, CID, LC-MS | Technique(s) used for Glycosylated Residue(s) Detection | HCD, ETD, CID | Glycan Information | Glycan Annotation | 1 or 2 Hex
between
73, 75, 77,
79, 81, 83,
84. | Literature | Year of Identification | 2014 | Year of Identification Month Wise | 2014.1.31 | Reference | Smith GT, Sweredoski MJ, Hess S (2014) O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins.J Proteomics, 97:296-306. [PubMed: 23702328] | Author | Smith, Geoffrey T., Michael J. Sweredoski, and Sonja Hess. | Research Group | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA | Corresponding Author | Sonja Hess. | Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA | | ||
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