ProGP551 (Pls (Plasmin sensitive surface protein))
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP551 (Pls (Plasmin sensitive surface protein)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Staphylococcus aureus strain 1061 |
| Domain | Bacteria |
| Classification | Family:Staphylococcaceae Order: Bacillales Class: Bacilli Division or phylum: "Firmicutes" |
| Taxonomic ID (NCBI) | 367830 |
| Genome Information | |
| GenBank | CP000255 |
| EMBL | CP000255 |
| Organism Additional Information | S. aureus is a human pathogen responsible for life-threatening infections as it is able to attach to surfaces, form biofilms, and persist inside the host. It causes mild skin infections and even serious and life-threatening infections, such as endocarditis, osteomyelitis, pneumonia, meningitis, and sepsis. |
| Gene Information | |
| Gene Name | pls |
| Protein Information | |
| Protein Name | Pls (Plasmin sensitive surface protein) |
| UniProtKB/SwissProt ID | P80544 |
| EMBL-CDS | AAD09131.2 |
| UniProtKB Sequence | >sp|P80544|PLS_STAAU Surface protein OS=Staphylococcus aureus GN=pls PE=1 SV=2 MNKNSKKKLDFLPNKLNKYSIRRFTVGTASILVGATLIFGVANDQAEAAENNTTQKQDDS SDASKVKGNVQTIEQSSANSNESDIPEQVDVTKDTTEQASTEEKANTTEQASTEEKADTT EQATTEEAPKAEGTDKVETEEAPKAEETDKATTEEAPKAEETDKATEEAPKTEETDKATT EEAPAAEETSKAATEEAPKAEETSKAATEEAPKAEETEKTATEEAPKTEETDKVETEEAP KAEETSKAATEKAPKAEETNKVETEEAPAAEETNKAATEETPAVEDTNAKSNSNAQPSET ERTQVVDTVAKDLYKKSEVTEAEKAEIEKVLPKDISNLSNEEIKKIALSEVLKETANKEN AQPRATFRSVSSNARTTNVNYSATALRAAAQDTVTKKGTGNFTAHGDIIHKTYKEEFPNE GTLTAFNTNFNPNTGTKGALEYNDKIDFNKDFTITVPVANNNQGNTTGADGWGFMFTQGN GQDFLNQGGILRDKGMANASGFKIDTAYNNVNGKVDKLDADKTNNLSQIGAAKVGYGTFV KNGADGVTNQVGQNALNTKDKPVNKIIYADNTTNHLDGQFHGQRLNDVVLNYDAATSTIT ATYAGKTWKATTDDLGIDKSQKYNFLITSSHMQNRYSNGIMRTNLEGVTITTPQADLIDD VEVTKQPIPHKTIREFDPTLEPGSPDVIVQKGEDGEKTTTTPTKVDPDTGDVVERGEPTT EVTKNPVDEIVHFTPEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDV TKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTTTTPTTINPLTGEK VGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEV VTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTTTTPTT INPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGI KNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGE KTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTE EVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETKRVLDPTMEPGSPDK VAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNYAPEIIPHGTREEID PNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADSDSDADSDSDADSDS DADSDSDADSDSDSDSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDSDADS DSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDA DSDSDADSDSDADSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDA DSDSDSDSDSDSDADSDSDADSDSDSDADSDSDADSDSDADGDSDADSDSDADSDSDSDS DSDSDSDSDADSDSDSDSDSDADRDHNDKTDKPNNKELPDTGNDAQNNGTLFGSLFAALG GLFLVGRRRKNKNNEEK |
| Sequence length | 1637 AA |
| Subcellular Location | Surface |
| Function | Pls is a virulence factor that reduces the adherence of S. aureus to Fg, Fn, or endothelial cells, internalization by human host cells and phagocytosis by polymorphonuclear neutrophils (PMNs) independently of its glycosylation status. |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser) linked |
| Technique(s) used for Glycosylation Detection | Periodic acid-Schiff staining |
| Protein Glycosylation- Implication | Biofilm formation (in S. aureus Newman) is enhanced upon expression of GtfC/GtfD-glycosylated Pls that may contribute to MRSA (methicillin-resistant S. aureus) pathogenicity. The glycoprotein may serve as a future antibacterial target to combat or prevent infections. |
| Glycan Information | |
| Glycan Annotation | N-acetylhexosaminyl residues |
| Protein Glycosylation linked (PGL) gene(s) | |
| OST ProGT ID | |
| Literature | |
| Reference | Bleiziffer I, Eikmeier J, Pohlentz G, McAulay K, Xia G, Hussain M, et al. (2017) The Plasmin-Sensitive Protein Pls in Methicillin-Resistant Staphylococcus aureus (MRSA) Is a Glycoprotein. PLoS Pathog 13(1): e1006110. doi:10.1371/journal.ppat.1006110 |
| Author | Bleiziffer I, Eikmeier J, Pohlentz G, McAulay K, Xia G, Hussain M, Peschel A, Foster S4, Peters G, Heilmann C. |
| Research Group | 1 Institute of Medical Microbiology, University of Münster, Münster, Germany. 2 Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany. 3 Institute for Hygiene, University of Münster, Münster, Germany. 4 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom. 5 Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. 6 Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany. 7 German Center for Infection Research (DZIF), partner site Tübingen, University of Tübingen, Tübingen, Germany. 8 Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany |
| Corresponding Author | Heilmann C |
| Contact | 1 Institute of Medical Microbiology, University of Münster, Münster, Germany. 2 Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany. |