ProGP57 (38 kDa antigen)
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| ProGP ID | ProGP57 (38 kDa antigen) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis H37Rv |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
| Taxonomic ID (NCBI) | 1773 |
| Genome Information | |
| GenBank | AL123456.3 |
| EMBL | BX842578 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Protein Information | |
| Protein Name | 38 kDa antigen |
| Function | It is a disease associated species-specific antigen that displays high immunogenicity at B- and T-cell levels. Two epitopes namely a carbohydrate-dependent and a carbohydrate-independent, have been identified on this antigen using TB71 and TB72 monoclonal antibodies. Owing to its highly specific recognition of patients with lung tuberculosis and its non-reactivity with normal sera. It has a great potential for the serological diagnosis of tuberculosis. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Schiff's reagent staining, peroxidase-conjugated concanavalin A (ConA)-binding |
| Glycan Information | |
| Glycan Annotation | 25.7% carbohydrate estimated by phenol-sulfuric acid assay. |
| Literature | |
| Year of Identification | 1989 |
| Year of Identification Month Wise | 1989.12 |
| Reference | Rosales‐Borjas, D.M., Zambrano‐Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. and Ortiz‐Ortiz, L., 1998. Rapid screening test for tuberculosis using a 38‐kDa antigen from Mycobacterium tuberculosis. Journal of clinical laboratory analysis, 12(2), pp.126-129. |
| Corresponding Author | L Ortiz-Ortiz |
| Contact | Miguel Oraá University Hospital, Guanare, Edo. Portuguesa, Venezuela. |
| Reference | Mehaffy, C., Belisle, J.T. and Dobos, K.M., 2019. Mycobacteria and their sweet proteins: An overview of protein glycosylation and lipoglycosylation in M. tuberculosis. Tuberculosis, 115, pp.1-13. |
| Corresponding Author | Carolina Mehaffy |
| Contact | Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus delivery, Fort Collins, CO, USA |
| Reference | Espitia, C. and Mancilla, R. (1989) Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol, 77, 378-383. [PubMed: 2478323] |
| Contact | Department of Immunology, National Autonomous University of Mexico, D.F |