| ProGT ID | ProGT33.6 (GtfH) |
| Organism Information | |
| Organism Name | Streptococcus agalactiae serotype III (strain NEM316) |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Lactobacillales Family : Streptococcaceae Genus : Stretococcus Species : agalactiae Strain : NEM316 |
| Taxonomic ID (NCBI) | 211110 |
| Genome Information | |
| Gene Bank | AL766851.1 |
| EMBL | AL766851.1 |
| Gene Information | |
| Gene Name | gbs1528 |
| NCBI Reference Sequence | CAD47187 |
| Protein information | |
| Protein Name | GtfH |
| UniProtKB/ SwissProt ID | Q8E474 |
| NCBI Ref Seq | WP_001263776.1 |
| UniProtKB Sequence | >tr|Q8E474|Q8E474_STRA3 Uncharacterized protein OS=Streptococcus agalactiae serotype III (strain NEM316) GN=gbs1528 PE=4 SV=1 MRVHITSIYGQSPRSIALISQKLVKDVGRQLGYDEMGIYFYNDHAETHGERSTRMDGIIA GLGRGDIVVFQVPTWNSTEFDELFLDKLQAYGARIITFVHDIVPLMFESNFYLLDRVIDM YNRSDVVILPTKAMHDYLIEKGMTTSKVLYQEVWDHPVNIDLPRPECQKVLSFAGDIQRF PFVNDWKENIPLIYYGDGSRLNSEANVHAQGWKDDVELMLSLSKRGGFGLCWSEDREELV ERRYSRMNASYKLSTFLAAGLPIIANHDISSRDFIKQHGLGFTVETLEEAVEKINNMEKE TYDSYVENVEKIATLLRNGYITKKLLIDAVHMLYR |
| EMBL CDS | CAD47187.1 |
| Sequence length | 335 AA |
| String | 211110.gbs1528. |
| Glycosylation Information | |
| EC Number (BRENDA) | 2.4.1.- |
| Experimental Validation | In vivo |
| Additional Information | 1) Srr1 is important for the virulence of S. agalactiae NEM316. 2) The reactivity of Srr1 toward lectin and the monosaccharide composition analysis of full-length protein showed that Srr1 was mainly modified with GlcNAc and Glc residues, strongly suggesting that HexNAc and Hex should correspond to these two sugars. |
| Litrature | |
| Year Of Validation | 2009 |
| Reference | Mistou, M.Y., Dramsi, S., Brega, S., Poyart, C. and Trieu-Cuot, P., 2009. Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulence. Journal of bacteriology, 191(13), pp.4195-4206. |
| Corresponding Author | Institut Pasteur, Biological Unit of Gram-Positive Pathogenic Bacteria, URA CNRS 2172, Paris Cedex 15, France. |
| Reference | Chaze, T., Guillot, A., Valot, B., Langella, O., Chamot-Rooke, J., Di Guilmi, A.M., Trieu-Cuot, P., Dramsi, S. and Mistou, M.Y., 2014. O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry. Molecular & Cellular Proteomics, 13(9), pp.2168-2182. |
| Corresponding Author | INRA, MICALIS UMR-1319, 78352 Jouy-en-Josas cedex, France |