ProGP245 (SraP (serine-rich adhesin for platelets)
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| ProGP ID | ProGP245 (SraP (serine-rich adhesin for platelets) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Staphylococcus aureus (ISP479C and PS767) |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Staphylococcaeae Genus : Staphylococcus Species : aureus Strain : ISP479C and PS767 |
| Taxonomic ID (NCBI) | 367830 |
| Genome Information | |
| GenBank | CP000255 |
| EMBL | CP000255 |
| Gene Information | |
| Gene Name | sraP |
| Protein Information | |
| Protein Name | SraP (serine-rich adhesin for platelets) |
| UniProtKB/SwissProt ID | Q2FUW1 |
| Sequence length | 2271 AA |
| Subcellular Location | Surface (Secreted) |
| Function | SraP, a cell wall-anchored glycoprotein, mediates the direct binding of S. aureus to platelets through a platelet-binding domain located within its N-terminal region. Its expression appears to be a virulence determinant in endovascular infection. |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Technique(s) used for Glycosylation Detection | Carbohydrate conntent analysis by glycan detection assay |
| Glycan Information | |
| Glycan Annotation | Glycosylated by GlcNAc-containing oligosaccharides in E. coli. |
| Protein Glycosylation linked (PGL) gene(s) | |
| OST ProGT ID | ProGT77 ProGT78 |
| Characterized Accessory Gene(s) | gtfA and gtfB |
| Additional Comment | E. coli was used as the in vivo glycosylation system for studying the glycosylation of SraP1-743 using GtfA and GtfB enzymes that transferred N-acetylglucosamine-containing oligosaccharides to the recombinant protein. |
| Literature | |
| Year of Identification | 2005 |
| Year of Identification Month Wise | 2005.04 |
| Reference | Siboo, I.R., Chambers, H.F. and Sullam, P.M., 2005. Role of SraP, a serine-rich surface protein of Staphylococcus aureus, in binding to human platelets. Infection and immunity, 73(4), pp.2273-2280. |
| Corresponding Author | Paul M Sullam |
| Contact | Division of Infectious Diseases, VA Medical Center (111W), 4150 Clement St., San Francisco, CA 94121, USA. |