ProGP110 (45 to 47-kDa protein)
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| ProGP ID | ProGP110 (45 to 47-kDa protein) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Mycobacterium bovis BCG |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis |
| Taxonomic ID (NCBI) | 410289 |
| Genome Information | |
| GenBank | AM408590.1 |
| EMBL | AM408590 |
| Organism Additional Information | Mycobacterium bovis is the etiologic agent of bovine tuberculosis. |
| Gene Information | |
| Gene Name | apa (BCG_1896) |
| NCBI Gene ID | 4695569 |
| GenBank Gene Sequence | NC_008769.1 |
| Protein Information | |
| Protein Name | 45- to 47-kDa protein |
| UniProtKB/SwissProt ID | P80069 |
| NCBI RefSeq | WP_003409337.1 |
| EMBL-CDS | CAL71883.1 |
| UniProtKB Sequence | >sp|P80069|APA_MYCBP Alanine and proline-rich secreted protein apa OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) GN=apa PE=1 SV=2 MHQVDPNLTRRKGRLAALAIAAMASASLVTVAVPATANADPEPAPPVPTTAASPPSTAAA PPAPATPVAPPPPAAANTPNAQPGDPNAAPPPADPNAPPPPVIAPNAPQPVRIDNPVGGF SFALPAGWVESDAAHLDYGSALLSKTTGDPPFPGQPPPVANDTRIVLGRLDQKLYASAEA TDSKAAARLGSDMGEFYMPYPGTRINQETVSLDANGVSGSASYYEVKFSDPSKPNGQIWT GVIGSPAANAPDAGPPQRWFVVWLGTANNPVDKGAAKALAESIRPLVAPPPAPAPAPAEP APAPAPAGEVAPTPTTPTPQRTLPA |
| Sequence length | 325 AA |
| Subcellular Location | Secreted |
| Function | Dominant immunogen |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Concanavalin A-binding, biotin-hydrazide labeling, partial deglycosylation with jack bean β-D-mannosidase |
| Glycan Information | |
| Glycan Annotation | Presence of α-D-mannosyl linkage. |
| Literature | |
| Year of Identification | 1995 |
| Year of Identification Month Wise | 1995.02 |
| Reference | Espitia, C., Espinosa, R., Saavedra, R., Mancilla, R., Romain, F., Laqueyrerie, A. and Moreno, C., 1995. Antigenic and structural similarities between Mycobacterium tuberculosis 50-to 55-kilodalton and Mycobacterium bovis BCG 45-to 47-kilodalton antigens. Infection and immunity, 63(2), pp.580-584. |
| Corresponding Author | Clara Espitia |
| Contact | Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom. |