ProGP1308 (AlpA/B)
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP1308 (AlpA/B) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Helicobacter pylori |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : Epsilonproteobacteria Orders : Campylobacterales Family : Campylobacteraceae Genus : Helicobacter Species : pylori |
| Taxonomic ID (NCBI) | 210 |
| Genome Information | |
| Organism Additional Information | It is a Gram-negative bacterium responsible for the gastrointestinal diseases worldwide. |
| Protein Information | |
| Protein Name | Adhesin protein |
| UniProtKB/SwissProt ID | A0PAR2 |
| NCBI RefSeq | CAB05386.1 |
| UniProtKB Sequence | >tr|A0PAR2|A0PAR2_HELPX Adhesin OS=Helicobacter pylori OX=210 GN=alpA PE=4 SV=1 MIKKNRTLFLSLALCASISYAEDDGGFFTVGYQLGQVMQDVQNPGGTKRDELARELNADV TNNILNNNTGGNVAGALSNAFSQYLYSLLGAYPEKLNGNDVSANALLGGAVGSGTCAAAG TASGNSLNTQSACTAAGYYWLPSLSNRVLSTIGSQTNYGTNTNFPNMQQQLTYLNAANVF FNAMNKALEAKNGASGTSGATGQNGQTYSQQAIQYLQGQQNILNNAANLLKQDELLLEAF NSAVAANIGNKEFNSAVFTGLVQGIIDQSQSVYNELSKNPISGSAFNNATLSKLTDQANA VQGRANQLPNALYNAQVTLDKINALNNQVKSMPYLPQFRAGNSRATNILNGFYTKVGYKQ FFGKKRNIGLRYYGFFSYNGASVGFRSTQNNVGLYTYGVGTDVLYNIFSRSYQNRSVDMG FFSGIQLAGETFQSTLRDDPNVKLHGKINNTHFQFLFDFGMRMNFGKLDGKSNRHNQHTV EFGVVVPTIYNTYYKSAGTTVKYFRPYSVYWSYGYSF |
| Subcellular Location | Outer membrane |
| Function | reduction in protease activity and enhancement of adhesin binding ability |
| Glycan Information | |
| Glycan Annotation | the glycans on these key adhesins may be comprised of heptose, galactose, fucose, and/or derivatives of these sugars |
| Literature | |
| Year of Identification | 2022 |
| Reference | Teng, K.W., Hsieh, K.S., Hung, J.S., Wang, C.J., Liao, E.C., Chen, P.C., Lin, Y.H., Wu, D.C., Lin, C.H., Wang, W.C. and Chan, H.L., 2022. Helicobacter pylori employs a general protein glycosylation system for the modification of outer membrane adhesins. Gut microbes, 14(1), p.2130650. |
| Corresponding Author | Mou-Chieh Kao |
| Contact | Institute of Molecular Medicine, College of Life Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan |