ProGP1309 (BabA/B)

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ProGP ID ProGP1309 (BabA/B)
Validation Status Uncharacterized
Organism Information
Organism NameHelicobacter pylori
Domain Bacteria
Classification Phylum : Proteobacteria
Class : Epsilonproteobacteria
Orders : Campylobacterales
Family : Campylobacteraceae
Genus : Helicobacter
Species : pylori
Taxonomic ID (NCBI) 210
Genome Information
Organism Additional Information It is a Gram-negative bacterium responsible for the gastrointestinal diseases worldwide.
Protein Information
Protein NameAdhesin protein
UniProtKB/SwissProt ID A0A0A8TSK2
NCBI RefSeq AAY28056.1
UniProtKB Sequence >tr|A0A0A8TSK2|A0A0A8TSK2_HELPX BabA OS=Helicobacter pylori OX=210 GN=babA PE=4 SV=1 MKKHILSLTLGSLLVSTLSAEDDGFYTSVGYQIGEAAQMVTNTKGIQQLSDNYENLSKLL TRYSKLNTFIQLASDPSAINAARENLGASAKNLIGDTKTSPAYQAVLLAINAAVGFWNVL GYATQCGGNGNQKSTSSTTIFNNEPGYRSTSITCSYNNLGIGREGVMSIDNMKKVNEAYQ ILQTALKNGLPALKENNGTLSEVKYTYTCSGGGNTNCDPSLFGITGTTNNGDGRNGGSVT KTQTIDGKQVTTTISSKVVDSGASGNTSRVSYTEITNQLSGVPDSAQALLAQASTLINTI NDACPWFSVTNKSGGPQMNPTSGGLCNFKEEISAIQKMITDAQELVNQTSVINSHEQTAP VGGNKPFNPFTDASFAQGMLANASAQAKMLDLSHQVGQTINPDNLSGNFKNFVTGFLATC NNPSTAGTGGTQGSVPGTVTTQTFASGCAYVEQTITNLNNSIAHFGTQEQQIQQAENIAD TLVHFKSRYSELGNTYNSITTALSKVPNAQSLQNVVSKKNNPYSPQGIETNYYLNQNTYN QIQTINQELGRNPFRKLGIVSSQTNNGAMNGIGIQVGYKQFFGQKRKWGARYYGFFDYNH AFIKSSFFNSASDVWTYGFGADALYNFINDKATNFLGKNNKLSVGLFGGIALAGTSWLNS EYVNLATVNNVYNAKINTANFQFLFNMGVRMNLARSKKKGSDHAAQHGIELGLKIPTINT NYYSFMGAELKYRRLYSVYLNYVFAY
Subcellular LocationOuter membrane
Function reduction in protease activity and enhancement of adhesin binding ability
Glycan Information
Glycan Annotation the glycans on these key adhesins may be comprised of heptose, galactose, fucose, and/or derivatives of these sugars
Literature
Year of Identification2022
ReferenceTeng, K.W., Hsieh, K.S., Hung, J.S., Wang, C.J., Liao, E.C., Chen, P.C., Lin, Y.H., Wu, D.C., Lin, C.H., Wang, W.C. and Chan, H.L., 2022. Helicobacter pylori employs a general protein glycosylation system for the modification of outer membrane adhesins. Gut microbes, 14(1), p.2130650.
Corresponding Author Mou-Chieh Kao
ContactInstitute of Molecular Medicine, College of Life Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan