ProGP195 (Streptococcal acid glycoprotein SAGP)
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP195 (Streptococcal acid glycoprotein SAGP) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Streptococcus pyogenes type M5 (Manfredo strain) |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Lactobacillales Family : Streptococcaceae Genus : Streptococcus Species : pyogenes Strain : Manfredo |
| Taxonomic ID (NCBI) | 160491 |
| Genome Information | |
| GenBank | AM295007.1 |
| EMBL | AM295007 |
| Gene Information | |
| Gene Name | sagP or arcA (SpyM50577) |
| NCBI Gene ID | 4964002 |
| GenBank Gene Sequence | NC_009332.1 |
| Protein Information | |
| Protein Name | Streptococcal acid glycoprotein SAGP |
| UniProtKB/SwissProt ID | P58827 |
| NCBI RefSeq | WP_011888729.1 |
| EMBL-CDS | CAM29914.1 |
| UniProtKB Sequence | >sp|P58827|ARCA_STRPG Arginine deiminase OS=Streptococcus pyogenes serotype M5 (strain Manfredo) GN=arcA PE=1 SV=3 MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQA LRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQEL IEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHM FSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRT DAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRV YSVTYDNEELHIIEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIA PGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI |
| Sequence length | 411 AA |
| Subcellular Location | Intracellular |
| Function | SAGP or its homolog,possesses AD (L-arginine deiminase) activity. The potent inhibition of proliferation of human T-cells by streptococcal CE is due to activity of this enzyme. |
| Literature | |
| Year of Identification | 2000 |
| Year of Identification Month Wise | 2000.06 |
| Reference | Degnan, B.A., Fontaine, M.C., Doebereiner, A.H., Lee, J.J., Mastroeni, P., Dougan, G., Goodacre, J.A. and Kehoe, M.A., 2000. Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infection and Immunity, 68(5), pp.2441-2448. |
| Corresponding Author | B A Degnan |
| Contact | School of Clinical Medical Sciences (Rheumatology), Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom. |
| Reference | Degnan, B.A., Palmer, J.M., Robson, T., Jones, C.E.D., Fischer, M., Glanville, M., Mellor, G.D., Diamond, A.G., Kehoe, M.A. and Goodacre, J.A., 1998. Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infection and Immunity, 66(7), pp.3050-3058. |
| Corresponding Author | B A Degnan |
| Contact | School of Clinical Medical Sciences (Rheumatology), Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom. |