ProGP22 (Flagellin FlaB1)
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| ProGP ID | ProGP22 (Flagellin FlaB1) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Treponema pallidum subsp. pallidum Nichols |
| Domain | Bacteria |
| Classification | Phylum : Spirochaetes Class : Spirochaetia Orders : Spirochaetales Family : Trepnemataceae Genus : Treponema Species : pallidum Subspecies : pallidum |
| Taxonomic ID (NCBI) | 160 |
| Genome Information | |
| GenBank | AE000520.1 |
| EMBL | AE000520 |
| Gene Information | |
| Gene Name | flaB1 (TP_0868) |
| NCBI Gene ID | 2611100 |
| GenBank Gene Sequence | NC_000919.1 |
| Protein Information | |
| Protein Name | Flagellin FlaB1 |
| UniProtKB/SwissProt ID | P21990 |
| NCBI RefSeq | WP_010882311.1 |
| EMBL-CDS | AAC65834.1 |
| UniProtKB Sequence | >sp|P21990|FLAB1_TREPA Flagellar filament 34.5 kDa core protein OS=Treponema pallidum GN=flaB1 PE=1 SV=2 MIINHNMSAMFAQRTLGHTNVQVGKGIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLN QASTNASNGVNFIQVTEAYLQETTDIMQRIRELAIQAANGIYSAEDRMQIQVEVSQLVAE VDRIASSAQFNGMNLLTGRFSRTEGENVIGGSMWFHIGANMDQRMRVYIGTMTAVALGVR NGVDESIMSIETADSANKSIGTIDAALKRINKQRADLGGYQNRMEYTVVGLDIAAENLQA AESRIRDANIAKQMVEYTKNQVLTQSGTAMLAQANTSAQSILSILR |
| Sequence length | 286 AA |
| Subcellular Location | Periplasm |
| Function | Flagellar 35 kDa core protein. It is the major component of the endoflagella which are required for motility of Treponemes. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Intrinsic [14C]glucosamine-labeling, periodate oxidation-DIG (digoxigenin) hydrazide labeling |
| Literature | |
| Year of Identification | 1984 |
| Year of Identification Month Wise | 1984.2 |
| Reference | Wyss, C., 1998. Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated. Infection and immunity, 66(12), pp.5751-5754. |
| Corresponding Author | C. Wyss |
| Contact | Institute for Oral Microbiology and General Immunology, Center for Dentistry, Oral and Maxillofacial Medicine at the University of Zurich, CH-8028 Zurich, Switzerland. |
| Reference | Moskophidis, M. and Müller, F., 1985. Identification of glycosylated protein antigens of Treponema pallidum and Treponema phagedenis. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology, 259(4), pp.468-476. |
| Corresponding Author | Ferdinand Muller |
| Contact | From the Department of Medicine, School of Medicine, University of Washington, Seattle, |
| Reference | Moskophidis, M.A.T.T.H.A.U.S. and Müller, F., 1984. Molecular characterization of glycoprotein antigens on surface of Treponema pallidum: comparison with nonpathogenic Treponema phagedenis biotype Reiter. Infection and immunity, 46(3), pp.867-869. |
| Corresponding Author | Ferdinand Muller |
| Contact | From the Department of Medicine, School of Medicine, University of Washington, Seattle, |