ProGP263 (Rv3491)
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| ProGP ID | ProGP263 (Rv3491) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis |
| Taxonomic ID (NCBI) | 1773 |
| Genome Information | |
| GenBank | AL123456.3 |
| EMBL | BX842583 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Gene Information | |
| Gene Name | (Rv3491) |
| NCBI Gene ID | 888382 |
| GenBank Gene Sequence | NC_000962.2 |
| Protein Information | |
| Protein Name | Rv3491 |
| UniProtKB/SwissProt ID | O06354 |
| NCBI RefSeq | NP_218008.1 |
| EMBL-CDS | AL123456.3 |
| UniProtKB Sequence | >tr|O06354|O06354_MYCTU Putative uncharacterized protein OS=Mycobacterium tuberculosis GN=MT3595 PE=4 SV=1 MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQ PSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGRARMSSMLWTFQVNQAD GVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSKQPFSLQLIGPPPSPVQR YPLYCNNIAMCY |
| Sequence length | 192 AA |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | S176 |
| Glycosite(s) Annotated Protein Sequence | >tr|O06354|O06354_MYCTU Putative uncharacterized protein OS=Mycobacterium tuberculosis GN=MT3595 PE=4 SV=1 MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQ PSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGRARMSSMLWTFQVNQAD GVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSKQPFSLQLIGPPPS*(176)PVQR YPLYCNNIAMCY |
| Sequence Around Glycosites (21 AA) | FSLQLIGPPPSPVQRYPLYCN |
| Technique(s) used for Glycosylation Detection | Concanavalin A (ConA) binding |
| Literature | |
| Year of Identification | 2009 |
| Year of Identification Month Wise | 2009.02 |
| Reference | González-Zamorano, M., Mendoza-Hernández, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C., 2009. Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. Journal of proteome research, 8(2), pp.721-733. |
| Corresponding Author | Clara Espitia |
| Contact | Immunology Department, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico. |
| Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. |
| Corresponding Author | Sonja Hess |
| Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA. |