ProGP264 (Glycosyl hydrolase)

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ProGP ID ProGP264 (Glycosyl hydrolase)
Validation Status Characterized
Organism Information
Organism NameMycobacterium tuberculosis
Domain Bacteria
Classification Phylum : Actinobacteria
Class : Actinomycetia
Orders : Corynebacteriales
Family : Mycobacteriaceae
Genus : Mycobacterium
Species : tuberculosis
Taxonomic ID (NCBI) 1773
Genome Information
GenBank AL123456.3
EMBL BX842575
Organism Additional Information It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens.
Gene Information
Gene NameRv1096
NCBI Gene ID 885949
GenBank Gene Sequence NC_000962.3
Protein Information
Protein NameGlycosyl hydrolase
UniProtKB/SwissProt ID O53444
NCBI RefSeq NP_215612.1
EMBL-CDSAL123456.3
UniProtKB Sequence >tr|O53444|O53444_MYCTU POSSIBLE GLYCOSYL HYDROLASE OS=Mycobacterium tuberculosis GN=MT1128 PE=4 SV=1 MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCSVIKCVALTFDDGPGPY TDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIGSHTWEHPNMTTIPPEDIP GQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVGQAEILWDVIPFDWINDSNTA ATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKANGYRLVTVSELLGPRAPGSSYG SRENGPPVNELRDIPASEIPPLPNTSSPKPMPNFPITDIAGQNSGGPNNGA
Sequence length 291 AA
Function Glycosyl hydrolase
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Experimentally Validated Glycosite(s) in Full Length ProteinT265, S266 and S267
Glycosite(s) Annotated Protein Sequence >tr|O53444|O53444_MYCTU POSSIBLE GLYCOSYL HYDROLASE OS=Mycobacterium tuberculosis GN=MT1128 PE=4 SV=1 MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCSVIKCVALTFDDGPGPY TDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIGSHTWEHPNMTTIPPEDIP GQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVGQAEILWDVIPFDWINDSNTA ATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKANGYRLVTVSELLGPRAPGSSYG SRENGPPVNELRDIPASEIPPLPNT*(265)S*(266)S*(267)PKPMPNFPITDIAGQNSGGPNNGA
Sequence Around Glycosites (21 AA) PASEIPPLPNTSSPKPMPNFP
ASEIPPLPNTSSPKPMPNFPI
SEIPPLPNTSSPKPMPNFPIT
ProGP Web Logo
Technique(s) used for Glycosylation DetectionConcanavalin A (ConA) binding
Literature
Year of Identification2009
Year of Identification Month Wise2009.02
ReferenceGonzález-Zamorano, M., Mendoza-Hernández, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C., 2009. Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. Journal of proteome research, 8(2), pp.721-733.
Corresponding Author Clara Espitia
ContactImmunology Department, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico.
ReferenceSmith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306.
Corresponding Author Sonja Hess
ContactProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA.