ProGP340 (FTH_1071)
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| ProGP ID | ProGP340 (FTH_1071) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Francisella tularensis ssp. holarctica strain FSC200 |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : Gammaproteobacteria Orders : Thiotrichales Family : Francisellaceae Genus : Francisella Species : tularensis Subspecies : holarctica Strain : FSC 200 |
| Taxonomic ID (NCBI) | 351581 |
| Genome Information | |
| GenBank | CP003862.1 |
| EMBL | CP003862.1 |
| Gene Information | |
| Gene Name | FTH_1071 |
| GenBank Gene Sequence | NC_008369.1 |
| Protein Information | |
| Protein Name | FTH_1071 |
| UniProtKB/SwissProt ID | Q19TM5 |
| NCBI RefSeq | WP_003019051.1 |
| EMBL-CDS | DQ451146.1 |
| UniProtKB Sequence | >tr|Q19TM5|Q19TM5_FRATU Conserved lipoprotein OS=Francisella tularensis subsp. holarctica GN=CH66_691 PE=4 SV=1 MTKKKLLKALAVAAIATSLVACSDSSSNDKTSTTAVSSGSSVATTTVAAPADNTNVTANA SYTIGYGMGSSIATDKNIKTFNFNNDKVMAGFEDAINAKKPAIPLEDIANNMNTLRDKMQ QQMNQKAVTSFLSVQDGIYNSDLTPKSDIKNPDVVVYEFFDYQCMYCSKLAPEIEKIMKD NSDVQVVFAEFPIFGQKLPASEYAAEVSTAIYKLYGADAYVKYHNGIFATGEDEGSLKNA TVDNVAKQAGADMTKVNKAIQDDKIADHLKDMLKMGFGQLGIQGAPFLVIAPAKNATVAN TTIIGGYTTADGIQAAINKAKSTATTTSTSNNGQTDTKHSQNDIATVTAEAQAISGSTEQ LAQQSQDDDSVEA |
| Sequence length | 373 AA |
| Subcellular Location | Membrane |
| Function | DsbA homologue, putative thioredoxin family protein |
| Protein Structure | |
| Protein Additional Information | DsbA homologue |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Experimentally Predicted Glycosites | T34, T45, T46, S32, S37 and S41 |
| Technique(s) used for Glycosylation Detection | Hydrazide labeling and lectin affinity chromatography. |
| Glycan Information | |
| Glycan Annotation | X-P-HexNAc-HexNAc-Hex-Hex-HexNAc, where X denotes the unknown monosaccharide containing a phosphate group |
| Technique(s) used for Glycan Identification | Mass spectrometry |
| Protein Glycosylation linked (PGL) gene(s) | |
| Characterized Accessory Gene(s) | FTS_1402 (ABC transporter) |
| Literature | |
| Year of Identification | 2010 |
| Year of Identification Month Wise | 2010.4.5 |
| Year of Validation | 2012 |
| Reference | Balonova, L., Hernychova, L., Mann, B.F., Link, M., Bilkova, Z., Novotny, M.V. and Stulik, J., 2010. Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis, an intracellular microorganism. Journal of proteome research, 9(4), pp.1995-2005. |
| Corresponding Author | Lenka Hernychova |
| Contact | Institute of Molecular Pathology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic |
| Reference | Balonova, L., Mann, B.F., Cerveny, L., Alley, W.R., Chovancova, E., Forslund, A.L., Salomonsson, E.N., Forsberg, Å., Damborsky, J., Novotny, M.V. and Hernychova, L., 2012. Characterization of protein glycosylation in Francisella tularensis subsp. holarctica: identification of a novel glycosylated lipoprotein required for virulence. Molecular & Cellular Proteomics, 11(7), pp.M111-015016. |
| Corresponding Author | Lenka Hernychova |
| Contact | Institute of Molecular Pathology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic |