ProGP452 (Probable conserved proline rich membrane protein (MT2222))
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP452 (Probable conserved proline rich membrane protein (MT2222)) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis H37Rv |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
| Taxonomic ID (NCBI) | 83332 |
| Genome Information | |
| GenBank | NC_000962.3 |
| EMBL | CP009480 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Gene Information | |
| Gene Name | Rv2164c |
| NCBI Gene ID | 887217 |
| GenBank Gene Sequence | NC_000962.3 |
| Protein Information | |
| Protein Name | Probable conserved proline rich membrane protein (MT2222) |
| UniProtKB/SwissProt ID | O06213 |
| NCBI RefSeq | NP_216680.1 |
| EMBL-CDS | CCP44941.3 |
| UniProtKB Sequence | >tr|O06213|O06213_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv2164c PE=1 SV=1 MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGP QTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERLAARLTSIDLRPRTLAN KVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASA PALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPADGVPPPPLNTKLPEDPPPPPKP AAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGATHLPTQAGPQLPGPVPIP GAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPAPVAATPGLSGGSQPMVAPPA PVPANGEQFGPVTAPVPTAPGAPR |
| Sequence length | 382 AA |
| Subcellular Location | Membrane |
| Glycosylation Status | |
| Glycosylation Type | O- (Thr) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | T252 |
| Glycosite(s) Annotated Protein Sequence | >tr|O06213|O06213_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv2164c PE=1 SV=1 MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGP QTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERLAARLTSIDLRPRTLAN KVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASA PALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPADGVPPPPLNTKLPEDPPPPPKP AAVPLEVPVRVT*(252)PGPDDPAPPARSGPEVLVRTPDGTATLGGATHLPTQAGPQLPGPVPIP GAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPAPVAATPGLSGGSQPMVAPPA PVPANGEQFGPVTAPVPTAPGAPR |
| Sequence Around Glycosites (21 AA) | AVPLEVPVRVTPGPDDPAPPA |
| Average Amino Acid Composition around Glycosite(s) | _VT(he)PGPDDPAPPAR_ |
| Technique(s) used for Glycosylation Detection | LC-MS (HCD) |
| Technique(s) used for Glycosylated Residue(s) Detection | HCD |
| Glycan Information | |
| Glycan Annotation | Hex |
| Literature | |
| Year of Identification | 2014 |
| Year of Identification Month Wise | 2014.1.31 |
| Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. |
| Corresponding Author | Sonja Hess |
| Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA |