ProGP456 (Rv3835)
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ProGP ID | ProGP456 (Rv3835) |
Validation Status | Characterized |
Organism Information | |
Organism Name | Mycobacterium tuberculosis H37Rv |
Domain | Bacteria |
Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
Taxonomic ID (NCBI) | 83332 |
Genome Information | |
GenBank | NC_000962.3 |
EMBL | CP009480 |
Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
Gene Information | |
Gene Name | Rv3835 |
NCBI Gene ID | 886168 |
GenBank Gene Sequence | NC_000962.3 |
Protein Information | |
Protein Name | Rv3835 |
UniProtKB/SwissProt ID | P96243/P9WKW5 |
NCBI RefSeq | NP_218352 |
EMBL-CDS | CCP46664.3 |
UniProtKB Sequence | >sp|P9WKW5|Y3835_MYCTU Uncharacterized membrane protein Rv3835 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv3835 PE=1 SV=1 AIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHMLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG |
Sequence length | 449 AA |
Subcellular Location | Membrane |
Glycosylation Status | |
Glycosylation Type | O- (Thr) linked |
Experimentally Validated Glycosite(s) in Full Length Protein | T373 |
Glycosite(s) Annotated Protein Sequence | >sp|P9WKW5|Y3835_MYCTU Uncharacterized membrane protein Rv3835 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv3835 PE=1 SV=1 AIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHMLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPT*(373)PRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG |
Sequence Around Glycosites (21 AA) | SGRSIQNKGITPDVPVDQYAD |
Average Amino Acid Composition around Glycosite(s) | LNLPPIPLQLPT(he)PR |
Technique(s) used for Glycosylation Detection | LC-MS (CID) |
Technique(s) used for Glycosylated Residue(s) Detection | neutral loss MS3, (CID) |
Glycan Information | |
Glycan Annotation | Hex |
Literature | |
Year of Identification | 2014 |
Year of Identification Month Wise | 2014.1.31 |
Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. |
Corresponding Author | Sonja Hess |
Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA |