ProGP550 (Pls (Plasmin sensitive surface protein))

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ProGP ID ProGP550 (Pls (Plasmin sensitive surface protein))
Validation Status Uncharacterized
Organism Information
Organism NameStaphylococcus aureus strain COL
Domain Bacteria
Classification Phylum : Firmicutes
Class : Bacilli
Orders : Bacillales
Family : Staphylococcaeae
Genus : Staphylococcus
Species : aureus
Strain : COL
Taxonomic ID (NCBI) 93062
Genome Information
GenBank CP000255
EMBL CP000255
Organism Additional Information S. aureus is a human pathogen responsible for life-threatening infections as it is able to attach to surfaces, form biofilms, and persist inside the host. It causes mild skin infections and even serious and life-threatening infections, such as endocarditis, osteomyelitis, pneumonia, meningitis, and sepsis.
Gene Information
Gene Namepls
Protein Information
Protein NamePls (Plasmin sensitive surface protein)
UniProtKB/SwissProt ID Q5HJU7
EMBL-CDSAAW38699.1
UniProtKB Sequence >sp|Q5HJU7|PLS_STAAC Putative surface protein SACOL0050 OS=Staphylococcus aureus (strain COL) GN=SACOL0050 PE=3 SV=1 MNKNSKKKLDFLPNKLNKYSIRRFTVGTASILVGATLIFGVANDQAEAAENNTTQKQDDS SDASKVKGNVQTIEQSSANSNESDIPEQVDVTKDTTEQASTEEKANTTEQASTEEKADTT EQATTEEAPKAEGTDKVETEEAPKAEETDKATEEAPKTEETDKATTEEAPKAEETDKATE EAPKTEETDKATTEEAPAAEETSKAATEEAPKAEETSKAATEEAPKAEETEKTATEEAPK TEETDKVETEEAPKAEETSKAATEKAPKAEETNKVETEEAPAAEETNKAATEETPAVEDT NAKSNSNAQPSETERTQVVDTVAKDLYKKSEVTEAEKAEIEKVLPKDISNLSNEEIKKIA LSEVLKETANKENAQPRATFRSVSSNARTTNVNYSATALRAAAQDTVTKKGTGNFTAHGD IIHKTYKEEFPNEGTLTAFNTNFNPNTGTKGALEYNDKIDFNKDFTITVPVANNNQGNTT GADGWGFMFTQGNGQDFLNQGGILRDKGMANASGFKIDTAYNNVNGKVDKLDADKTNNLS QIGAAKVGYGTFVKNGADGVTNQVGQNALNTKDKPVNKIIYADNTTNHLDGQFHGQRLND VVLNYDAATSTITATYAGKTWKATTDDLGIDKSQKYNFLITSSHMQNRYSNGIMRTNLEG VTITTPQADLIDDVEVTKQPIPHKTIREFDPTLEPGSPDVIVQKGEDGEKTTTTPTKVDP DTGDVVERGEPTTEVTKNPVDEIVHFAPEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNP ETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTT TTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVP GKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQE GQTGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLP IDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETKRVLDPTMEP GSPDKVAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNYAPEIIPHGT REEIDPNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADSDSDADSDSD ADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDSDSDSDADSDSDADSDSD ADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSD ADSDSDSDSDSDSDADSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSD SDSDRDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDSDADSDSDSD SDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDADRDHNDK TDKPNNKELPDTGNDAQNNGTLFGSLFAALGGLFLVGRRRKNKNNEEK
Sequence length 1548 AA
Subcellular LocationSurface
Function Pls is a virulence factor that reduces the adherence of S. aureus to Fg, Fn, or endothelial cells, internalization by human host cells and phagocytosis by polymorphonuclear neutrophils (PMNs) independently of its glycosylation status.
Glycosylation Status
Glycosylation Type O- (Ser) linked
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Technique(s) used for Glycosylation DetectionPeriodic acid-Schiff staining
Protein Glycosylation- Implication Biofilm formation (in S. aureus Newman) is enhanced upon expression of GtfC/GtfD-glycosylated Pls that may contribute to MRSA (methicillin-resistant S. aureus) pathogenicity. The glycoprotein may serve as a future antibacterial target to combat or prevent infections.
Glycan Information
Glycan Annotation N-acetylhexosaminyl residues
Protein Glycosylation linked (PGL) gene(s)
OST ProGT IDProGT66 ProGT67
Characterized Accessory Gene(s)gtfC, gtfD, sdgA and sdgB
Literature
Year of Identification2017
Year of Identification Month Wise2017.1.12
ReferenceBleiziffer, I., Eikmeier, J., Pohlentz, G., McAulay, K., Xia, G., Hussain, M., Peschel, A., Foster, S., Peters, G. and Heilmann, C., 2017. The plasmin-sensitive protein Pls in methicillin-resistant Staphylococcus aureus (MRSA) is a glycoprotein. PLoS pathogens, 13(1), p.e1006110.
Corresponding Author Christine Heilmann
ContactInstitute of Medical Microbiology, University of Münster, Münster, Germany, Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany