ProGP551 (Pls (Plasmin sensitive surface protein))
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| ProGP ID | ProGP551 (Pls (Plasmin sensitive surface protein)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Staphylococcus aureus strain 1061 |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Staphylococcaeae Genus : Staphylococcus Species : aureus Strain : COL |
| Taxonomic ID (NCBI) | 93062 |
| Genome Information | |
| GenBank | CP000255 |
| EMBL | CP000255 |
| Organism Additional Information | S. aureus is a human pathogen responsible for life-threatening infections as it is able to attach to surfaces, form biofilms, and persist inside the host. It causes mild skin infections and even serious and life-threatening infections, such as endocarditis, osteomyelitis, pneumonia, meningitis, and sepsis. |
| Gene Information | |
| Gene Name | pls |
| Protein Information | |
| Protein Name | Pls (Plasmin sensitive surface protein) |
| UniProtKB/SwissProt ID | P80544 |
| EMBL-CDS | AAD09131.2 |
| UniProtKB Sequence | >sp|P80544|PLS_STAAU Surface protein OS=Staphylococcus aureus GN=pls PE=1 SV=2 MNKNSKKKLDFLPNKLNKYSIRRFTVGTASILVGATLIFGVANDQAEAAENNTTQKQDDS SDASKVKGNVQTIEQSSANSNESDIPEQVDVTKDTTEQASTEEKANTTEQASTEEKADTT EQATTEEAPKAEGTDKVETEEAPKAEETDKATTEEAPKAEETDKATEEAPKTEETDKATT EEAPAAEETSKAATEEAPKAEETSKAATEEAPKAEETEKTATEEAPKTEETDKVETEEAP KAEETSKAATEKAPKAEETNKVETEEAPAAEETNKAATEETPAVEDTNAKSNSNAQPSET ERTQVVDTVAKDLYKKSEVTEAEKAEIEKVLPKDISNLSNEEIKKIALSEVLKETANKEN AQPRATFRSVSSNARTTNVNYSATALRAAAQDTVTKKGTGNFTAHGDIIHKTYKEEFPNE GTLTAFNTNFNPNTGTKGALEYNDKIDFNKDFTITVPVANNNQGNTTGADGWGFMFTQGN GQDFLNQGGILRDKGMANASGFKIDTAYNNVNGKVDKLDADKTNNLSQIGAAKVGYGTFV KNGADGVTNQVGQNALNTKDKPVNKIIYADNTTNHLDGQFHGQRLNDVVLNYDAATSTIT ATYAGKTWKATTDDLGIDKSQKYNFLITSSHMQNRYSNGIMRTNLEGVTITTPQADLIDD VEVTKQPIPHKTIREFDPTLEPGSPDVIVQKGEDGEKTTTTPTKVDPDTGDVVERGEPTT EVTKNPVDEIVHFTPEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDV TKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTTTTPTTINPLTGEK VGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEV VTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTTTTPTT INPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGI KNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGE KTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTE EVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETKRVLDPTMEPGSPDK VAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNYAPEIIPHGTREEID PNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADSDSDADSDSDADSDS DADSDSDADSDSDSDSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDSDADS DSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDA DSDSDADSDSDADSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDA DSDSDSDSDSDSDADSDSDADSDSDSDADSDSDADSDSDADGDSDADSDSDADSDSDSDS DSDSDSDSDADSDSDSDSDSDADRDHNDKTDKPNNKELPDTGNDAQNNGTLFGSLFAALG GLFLVGRRRKNKNNEEK |
| Sequence length | 1637 AA |
| Subcellular Location | Surface |
| Function | Pls is a virulence factor that reduces the adherence of S. aureus to Fg, Fn, or endothelial cells, internalization by human host cells and phagocytosis by polymorphonuclear neutrophils (PMNs) independently of its glycosylation status. |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser) linked |
| Technique(s) used for Glycosylation Detection | Periodic acid-Schiff staining |
| Protein Glycosylation- Implication | Biofilm formation (in S. aureus Newman) is enhanced upon expression of GtfC/GtfD-glycosylated Pls that may contribute to MRSA (methicillin-resistant S. aureus) pathogenicity. The glycoprotein may serve as a future antibacterial target to combat or prevent infections. |
| Glycan Information | |
| Glycan Annotation | N-acetylhexosaminyl residues |
| Protein Glycosylation linked (PGL) gene(s) | |
| OST ProGT ID | ProGT66 ProGT67 |
| Characterized Accessory Gene(s) | gtfC, gtfD, sdgA and sdgB |
| Literature | |
| Year of Identification | 2017 |
| Year of Identification Month Wise | 2017.01.12 |
| Reference | Bleiziffer, I., Eikmeier, J., Pohlentz, G., McAulay, K., Xia, G., Hussain, M., Peschel, A., Foster, S., Peters, G. and Heilmann, C., 2017. The plasmin-sensitive protein Pls in methicillin-resistant Staphylococcus aureus (MRSA) is a glycoprotein. PLoS pathogens, 13(1), p.e1006110. |
| Corresponding Author | Christine Heilmann |
| Contact | Institute of Medical Microbiology, University of Münster, Münster, Germany, Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany |