ProGP715 (LpqH)
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ProGP ID | ProGP715 (LpqH) |
Validation Status | Characterized |
Organism Information | |
Organism Name | Mycobacterium tuberculosis |
Domain | Bacteria |
Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
Taxonomic ID (NCBI) | 83332 |
Genome Information | |
GenBank | CP016794.1 |
Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
Protein Information | |
Protein Name | LpqH |
NCBI RefSeq | ANZ84535 |
UniProtKB Sequence | >ANZ84535.1 LpqH [Mycobacterium tuberculosis] MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS |
Glycosylation Status | |
Glycosylation Type | O- (Ser/Thr) linked |
Experimentally Predicted Glycosites | T-40, T-41, S-43, S-48 |
Experimentally Validated Glycosite(s) in Full Length Protein | T-40, T-41, S-43, S-48 |
Experimentally Validated Glycosite(s ) in Mature Protein | >ANZ84535.1 LpqH [Mycobacterium tuberculosis] MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGT*(40)T*(41)AS*(43)PGAAS*(48)GPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS |
Glycosite(s) Annotated Protein Sequence | GSGETTTAAGTTASPGAASGP SGETTTAAGTTASPGAASGPK ETTTAAGTTASPGAASGPKVV AGTTASPGAASGPKVVIDGKD |
Technique(s) used for Glycosylation Detection | Nano-LC-MS/MS analysis |
Protein Glycosylation- Implication | Mannose |
Literature | |
Year of Identification | 2019 |
Reference | Birhanu, A.G., Yimer, S.A., Kalayou, S., Riaz, T., Zegeye, E.D., Holm-Hansen, C., Norheim, G., Aseffa, A., Abebe, M. and Tønjum, T., 2019. Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex. Scientific reports, 9(1), pp.1-15. |
Corresponding Author | Alemayehu Godana Birhanu Tone Tønjum |
Contact | 1. Department of Microbiology, University of Oslo, PO Box 4950, Nydalen, NO-0424, Oslo, Norway. 2. Addis Ababa University, Institute of Biotechnology, PO Box 1176, Addis Ababa, Ethiopia. 1. Department of Microbiology, University of Oslo, PO Box 4950, Nydalen, NO-0424, Oslo, Norway. 2. International Center of Insect Physiology and Ecology (ICIPE), P.O. Box 30772-00100, Nairobi, Kenya. |