ProGP716 (AcpM)
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| ProGP ID | ProGP716 (AcpM) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
| Taxonomic ID (NCBI) | 83332 |
| Genome Information | |
| GenBank | CP012506.2 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Protein Information | |
| Protein Name | AcpM |
| NCBI RefSeq | ALB19433 |
| UniProtKB Sequence | >ALB19433.1 AcpM [Mycobacterium tuberculosis] MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVANVQARLEAESK |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Experimentally Predicted Glycosites | S-41, S-43, T-51 |
| Experimentally Validated Glycosite(s) in Full Length Protein | S-41, S-43, T-51 |
| Experimentally Validated Glycosite(s ) in Mature Protein | >ALB19433.1 AcpM [Mycobacterium tuberculosis] MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDS*(41)LS*(43)MVEIAVQT*(51)EDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVANVQARLEAESK |
| Glycosite(s) Annotated Protein Sequence | KSFVDDLDIDSLSMVEIAVQT FVDDLDIDSLSMVEIAVQTED SLSMVEIAVQTEDKYGVKIPD |
| Technique(s) used for Glycosylation Detection | Nano-LC-MS/MS analysis |
| Protein Glycosylation- Implication | Mannose |
| Literature | |
| Year of Identification | 2019 |
| Reference | Birhanu, A.G., Yimer, S.A., Kalayou, S., Riaz, T., Zegeye, E.D., Holm-Hansen, C., Norheim, G., Aseffa, A., Abebe, M. and Tønjum, T., 2019. Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex. Scientific reports, 9(1), pp.1-15. |
| Corresponding Author | Alemayehu Godana Birhanu Tone Tønjum |
| Contact | 1. Department of Microbiology, University of Oslo, PO Box 4950, Nydalen, NO-0424, Oslo, Norway. 2. Addis Ababa University, Institute of Biotechnology, PO Box 1176, Addis Ababa, Ethiopia. 1. Department of Microbiology, University of Oslo, PO Box 4950, Nydalen, NO-0424, Oslo, Norway. 2. International Center of Insect Physiology and Ecology (ICIPE), P.O. Box 30772-00100, Nairobi, Kenya. |