ProGP928 (Orotidine 5'-phosphate decarboxylase)

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ProGP ID ProGP928 (Orotidine 5'-phosphate decarboxylase)
Validation Status Uncharacterized
Organism Information
Organism NameEhrlichia ruminantium
Domain Bacteria
Classification Phylum : Proteobacteria
Class : Alphaproteobacteria
Orders : Rickettsiales
Family : Anaplasmataceae
Genus : Ehrlichia
Species : ruminantium
Strain : Gardel
Taxonomic ID (NCBI) 302409
Genome Information
Organism Additional Information Ehrlichia ruminantium is an obligate intracellular bacterium that causes heartwater, a fatal tick-borne disease of livestock
Gene Information
Gene NamepyrF
NCBI Gene ID NC_006831.1
Protein Information
Protein NameOrotidine 5'-phosphate decarboxylase
UniProtKB/SwissProt ID Q5FHG2
UniProtKB Sequence >tr|Q5FHG2|Q5FHG2_EHRRG Orotidine 5'-phosphate decarboxylase OS=Ehrlichia ruminantium (strain Gardel) OX=302409 GN=pyrF MKHNPIICALDTHDIHKALRLTKMLYEKISMVKLGLEFFVAHGISGVQRISDCGIPIFLDLKLHDIPNTVSRAISVIKSLNIAMLTIHISGGQEMMKRTMDVIFDSMLKIIGVTVLTSIDVCDLKEIGIGNSTVQQVILLSKLAQKVGLYGIVCSPLEVKEVRAQCDKDLKIIVPGIRLGDNIDDQKRTDSPKSAILSGADYLVIGRPITENTDPVKVVDIILSSIADLHN
Subcellular LocationCytosol
Function Pyrimidine biosynthesis
Glycosylation Status
Technique(s) used for Glycosylation DetectionnLC–MS/MS Analysis
Literature
Year of Identification2019
ReferenceMarcelino, I., Colomé-Calls, N., Holzmuller, P., Lisacek, F., Reynaud, Y., Canals, F. and Vachiéry, N., 2019. Sweet and sour ehrlichia: Glycoproteomics and phosphoproteomics reveal new players in Ehrlichia ruminantium physiology and pathogenesis. Frontiers in microbiology, 10, p.450.
Corresponding Author Isabel Marcelino
Contact1. CIRAD, UMR ASTRE, Petit-Bourg, France.
2. ASTRE, CIRAD, INRA, Université de Montpellier, Montpellier, France.
3. Unitè TReD-Path (Transmission Rèservoirs et Diversitè des Pathogènes), Institut Pasteur de Guadeloupe, Les Abymes, France.