ProGT ID | ProGT75.5 (GlyE) |
Organism Information | |
Organism Name | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Domain | Bacteria |
Classification | Phylum : Firmicutes Class : Bacilli Orders : Lactobacillales Family : Streptococcaceae Genus : Streptococcus Species : pneumoniae Strain : ATCC BAA-334 / TIGR4 |
Taxonomic ID (NCBI) | 170187 |
Genome Information | |
Gene Bank | AE005672.3 |
EMBL | AE005672.3 |
Gene Information | |
Gene Name | glyE (SP_1766) |
Protein information | |
Protein Name | GlyE |
UniProtKB/ SwissProt ID | A0A0H2URJ6 |
NCBI Ref Seq | WP_001808456.1 |
UniProtKB Sequence | >tr|A0A0H2URJ6|A0A0H2URJ6_STRPN Glycosyl transferase, family 8 OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_1766 PE=4 SV=1 MRNTKRAVVFAGDYAYIRQIETAMKSLCRHNSHLKIYLLNQDIPQEWFSQIRIYLQEMGG DLIDCKLIGSQFQMNWSNKLPHINHMTFARYFIPDFVTEDKVLYLDSDLIVTGDLTDLFE LDLGENYLAAARSCFGAGVGFNAGVLLINNKKWGSETIRQKLIDLTEKEHENVEEGDQSI LNMLFKDQYSSLEDQYNFQIGYDYGAATFKHQFIFDIPLEPLPLILHYISQDKPWNQFSV GRLREVWWEYSLMDWSVILNEWFSKSVKYPSKSQIFKLQCVNLTNSWCVEKIDYLAEQLP EVHFHIVAYTNMANELLALTRFPNVTVYPNSLPMLLEQIVIASDLYLDLNHDRKLEDAYE FVLKYKKPMIAFDNTCSENLSEISYEGIYPSSIPKKMVAAIRSYMR |
EMBL CDS | AAK75841 |
Sequence length | 406 AA |
PDB ID (Structural Information) | 5GVV, 5GVW |
Glycosylation Information | |
Sugar Donor Specificity | UDP-Gal |
Acceptor Substrate Specificity | SRR1-GlcNAc-Glc-Glc |
Experimental Validation | In vivo and In vitro |
Product | SRR1-GlcNAc-Glc-Glc-Gal |
Donor Specificity | UDP-Gal |
Function in Glycosylation pathway | 1) GlyE is galactosyltransferase uses UDP-Gal as the donor, SRR1-GlcNAc-Glc-Glc is further modified to produce SRR1-GlcNAc-Glc-Glc-Gal. |
Additional Information | 1) GlyE shows a higher hydrolytic activity toward UDP-Glc compared with UDP-Gal. |
Litrature | |
Year Of Validation | 2017 |
Reference | Jiang, Y.L., Jin, H., Yang, H.B., Zhao, R.L., Wang, S., Chen, Y. and Zhou, C.Z., 2017. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. Journal of Biological Chemistry, 292(15), pp.6213-6224. |
Corresponding Author | 1 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China. |
Reference | Jiang, Y.L., Jin, H., Yang, H.B., Zhao, R.L., Wang, S., Chen, Y. and Zhou, C.Z., 2017. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. Journal of Biological Chemistry, 292(15), pp.6213-6224. |
Corresponding Author | 1 Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China. |