ProGT123 (TarS)
| ProGT ID | ProGT123 (TarS) |
| Organism Information | |
| Organism Name | Staphylococcus aureus |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Staphylococcaceae Genus : Staphylococcus Species : aureus |
| Taxonomic ID (NCBI) | 1280 |
| Genome Information | |
| Gene Information | |
| Gene Name | tars |
| Protein information | |
| Protein Name | WTA |
| UniProtKB/ SwissProt ID | A0A0H3JNB0 |
| UniProtKB Sequence | >sp|A0A0H3JNB0|TARP_STAAN Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase TarP OS=Staphylococcus aureus (strain N315) OX=158879 GN=tarP PE=1 SV=1 MKKVSVIMPTFNNGEKLHRTISSVLNQTMKSTDYELIIIDDHSNDNGETLNVIKKYKGLV RFKQLKKNSGNASVPRNTGLKMSKAEYVFFLDSDDLLHERALEDLYNYGKENNSDLIIGK YGVEGKGRSVPKAIFEKGNVAKADIIDNSIFYALSVLKMFKKSVIDKNKIKFKTFSKTAE DQLFTIEFLMNSKNYSIKTDYEYYIVVNDFESSNHLSVNKSTGNQYFATINEIYKAIYKS PIYKNQEKRHQLAGKYTTRLLRHGQKKNFANSKMKYEDKIEWLNNFSKTINKVPRDSDKY VTQIFNLKLEAIRQNDLLAVMIADKLL |
| Sequence length | 327AA |
| Subcellular Location | Cell wall |
| Function in Native Organism | Beta-lactam resistance, invasiveness and virulence |
| Glycosyltransferase Information | |
| Glycosylation Type | C-linked |
| Donor Type | UDP-GlcNac |
| Donor Specificity | Nucleotide activated sugars |
| Glycan Information | |
| Glycan transferred | Monosaccharide (GlcNac) |
| Method of Glycan Indentification | NMR spectroscopy |
| Experimental_strategies | In vivo and In vitro |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | WTA |
| ProGPdb ID | ProGP702 |
| Litrature | |
| Year Of Validation | 2012 |
| Reference | Brown, S., Xia, G., Luhachack, L.G., Campbell, J., Meredith, T.C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J.E., Peschel, A. and Walker, S., 2012. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proceedings of the national academy of sciences, 109(46), pp.18909-18914. |
| Corresponding Author | a. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; b. Cellular and Molecular Microbiology Section, Interfaculty
Institute of Microbiology and Infection Medicine, University of Tübingen, Elfriede-Aulhorn-Strasse 6, D-72076 Tübingen, Germany |
| Reference | Gerlach, D., Guo, Y., De Castro, C., Kim, S.H., Schlatterer, K., Xu, F.F., Pereira, C., Seeberger, P.H., Ali, S., Codée, J. and Sirisarn, W., 2018. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature, 563(7733), pp.705-709. |
| Corresponding Author | 11. Department of Chemical Sciences, University of Naples, Naples, Italy.
12. Vanderbilt University School of Medicine, Nashville, TN, USA. 13. These authors contributed equally: David Gerlach, Yinglan Guo. 14These authors jointly supervised this work: Thilo Stehle,
Andreas Peschel. |
| Reference | Winstel, V., Kühner, P., Salomon, F., Larsen, J., Skov, R., Hoffmann, W., Peschel, A. and Weidenmaier, C., 2015. Wall teichoic acid glycosylation governs Staphylococcus aureus nasal colonization. MBio, 6(4), pp.e00632-15. |
| Corresponding Author | 11. Department of Chemical Sciences, University of Naples, Naples, Italy.
12. Vanderbilt University School of Medicine, Nashville, TN, USA. 13. These authors contributed equally: David Gerlach, Yinglan Guo. 14These authors jointly supervised this work: Thilo Stehle,
Andreas Peschel. |