ProGT124 (TarP)
| ProGT ID | ProGT124 (TarP) |
| Organism Information | |
| Organism Name | Staphylococcus aureus |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Staphylococcaceae Genus : Staphylococcus Species : aureus |
| Taxonomic ID (NCBI) | 1280 |
| Genome Information | |
| Gene Information | |
| Gene Name | tarp |
| Protein information | |
| Protein Name | WTA |
| UniProtKB/ SwissProt ID | A0A0H3JVA1 |
| UniProtKB Sequence | >sp|A0A0H3JVA1|TARS_STAAW Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase TarS OS=Staphylococcus aureus (strain MW2) OX=196620 GN=tarS PE=1 SV=1 MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNL KVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIK MKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTTLLKDNDIYFPEELKSAEDQ LFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVMRLIAVEILNADLEE AHKDQILAEFLNRHFSFSRTNGFSLKVKLEDQPQWINALGDFIQAVPERVDALVMSKLRP LLHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTA FKFDNHKIVTELTLNEFMIGEGHYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDI KAYLPKEKIWDVFLEVQIGTEVFEVRVGNQRNKYAYTAETSALIHLNNDFYRLTPYFTKD FNNISLYFTAITLTDSISLKLKGKNKIILTGLDRGYVFEEGMASVVLKDDMIMGMLSQTS ENEVEILLSKDIKKRDFKNIVKLNTAHMTYSLK |
| Sequence length | 573 AA |
| Subcellular Location | Cell wall |
| Function in Native Organism | Beta-lactam resistance, invasiveness and virulence |
| Glycosyltransferase Information | |
| Glycosylation Type | C-linked |
| Donor Type | UDP-GlcNac |
| Donor Specificity | Nucleotide activated sugars |
| Glycan Information | |
| Glycan transferred | Monosaccharide (GlcNac) |
| Method of Glycan Indentification | NMR spectroscopy |
| Experimental_strategies | In vivo and In vitro |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | WTA |
| ProGPdb ID | ProGP702 |
| Litrature | |
| Year Of Validation | 2015 |
| Reference | Winstel, V., Kühner, P., Salomon, F., Larsen, J., Skov, R., Hoffmann, W., Peschel, A. and Weidenmaier, C., 2015. Wall teichoic acid glycosylation governs Staphylococcus aureus nasal colonization. MBio, 6(4), pp.e00632-15. |
| Corresponding Author | Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germanya; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany |
| Reference | Gerlach, D., Guo, Y., De Castro, C., Kim, S.H., Schlatterer, K., Xu, F.F., Pereira, C., Seeberger, P.H., Ali, S., Codée, J. and Sirisarn, W., 2018. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature, 563(7733), pp.705-709. |
| Corresponding Author | 11. Department of Chemical Sciences, University of Naples, Naples, Italy.
12. Vanderbilt University School of Medicine, Nashville, TN, USA. 13. These authors contributed equally: David Gerlach, Yinglan Guo. 14These authors jointly supervised this work: Thilo Stehle,
Andreas Peschel. |
| Reference | Missiakas, D., 2019. Staphylococcus aureus TarP: A brick in the wall or rosetta stone?. Cell host & microbe, 25(2), pp.182-183. |
| Corresponding Author | Department of Microbiology, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA |