ProGT145 (GccA)
| ProGT ID | ProGT145 (GccA) |
| Organism Information | |
| Organism Name | Lactobacillus plantarum KW30 |
| Clinical Implication | Non-pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Lactobacillales Family : Lactobacillaceae Genus : Lactobacillus Species : plantarum Strain : KW30 |
| Taxonomic ID (NCBI) | 1590 |
| Genome Information | |
| Gene Bank | GU552553.1 |
| Gene Information | |
| Gene Name | gccA |
| NCBI Reference Sequence | ADV57361.1 |
| Protein information | |
| Protein Name | GccA |
| UniProtKB/ SwissProt ID | E9K9Y6 |
| NCBI Ref Seq | ADV57361 |
| UniProtKB Sequence | >tr|E9K9Y6|E9K9Y6_LACPN UDP-GlcNAc glycosyltransferase family 2 OS=Lactiplantibacillus plantarum OX=1590 GN=gccA PE=4 SV=1 MKNRQNEIDSYLNLHLRPVHKSFDFGNLTNIDQFRHHIYVSYIVICKNSQATIERCVNSIAQNMENGDELIVLDTGSTDETVHLVKKNMPQAKISVTNWKNDFSEVRNKALKLASKDWVFYVDSDEWLDVDDGAQLKKILFKVQAKNFKFVINPTFSDHSGQIYQTVGRIFPKKSSFHYYAKIHEEVRKEDQKLGYDVRHFACDDIILYHDGYDKEVLRDKDKIKRNIRLLQEMTCEEPQNARWPFLLARDGFDVLPQDKLKQLVKRTLDLVASDSLQEKYSPFAKKLLGRILLREGKTTQAVLSFKDVLQITGGEDSDAIYYIESFKINEIIAEAKSIEVKMLRYLNKHKGMIDVNSDISGNYYHIAQVILECDIISANYSHLFPLISEIPKNFSGDIKSSVKSAVKLYSKLQGDSKNENN |
| Sequence length | 422AA |
| Function in Native Organism | It is S-glycosyltransferase, catalyzes GccF, glycocin has antimicrobial activity |
| Glycosyltransferase Information | |
| Glycosylation Type | O- (Ser) and S- (Cys) linked |
| CAZY Family | GT2 |
| Mechanism of Glycan Transfer | Sequential |
| Donor Type | UDP-GalNAc |
| Donor Specificity | Nucleotide activated sugars |
| Glycan Information | |
| Glycan transferred | Monosaccharide (GlcNac) |
| Experimental_strategies | in vivo |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | Glycocin F |
| ProGPdb ID | ProGP402 (Glycocin F) |
| Litrature | |
| Year Of Validation | 2021 |
| Reference | Drummond, B.J., Loo, T.S., Patchett, M.L. and Norris, G.E., 2021. Optimized Genetic Tools Allow the Biosynthesis of Glycocin F and Analogues Designed To Test the Roles of gcc Cluster Genes in Bacteriocin Production. Journal of bacteriology, 203(7), pp.e00529-20. |
| Corresponding Author | School of Fundamental Sciences, Massey University, Palmerston North, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand |