ProGT21 (PglO)

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ProGT ID ProGT21 (PglO)
ProGT Pathway
Organism Information
Organism NameNeisseria gonorrhoeae N400
Clinical ImplicationPathogenic
DomainBacteria
Classification Phylum : Proteobacteria
Class : BetaProteobacteria
Orders : Neisseriales
Family : Neisseriaceae
Genus : Neisseria
Species : gonorrhoeae
Strain : N400
Taxonomic ID (NCBI)242231
Genome Information
Gene BankAE004969.1
EMBLAE004969
Gene Information
Gene NameNGO0178
NCBI Gene ID3281327
NCBI Reference SequenceAAW88933
Protein information
Protein NamePglO 
UniProtKB/ SwissProt IDQ5FA54
NCBI Ref SeqWP_003690624.1
UniProtKB Sequence>tr|Q5FA54|Q5FA54_NEIG1 Polymerase OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) GN=NGO_0178 PE=4 SV=1 MSAETTVSGARPAAKLPIYILPCFLWIGIIPFTFALRLKPSPDFYHDAAAAAGLIVLLFL TAGKKLFDVKIPAISFLLFAMAAFWWLQARLMNLIYPGMNDIASWVFILLAVSAWACKSL VAHYGQERIVTLFAWSLLIGSLLQSCIVVIQFAGWENTPLLQNIIVHRGQGVIGHIGQRN NLGHYLMWGILASAYLNGQRKIPAALGAICLIMQTAVLGLVNSRTILTYIAAIALILPFW YFRSDKSNRRTMLGIAAAVFLTALFQFSMNAILETFTGIRYETAVERVANGGFTDLPRQS EWNKALAAFQSAPIFGHGWNSFAQQTFLINAEQHTIHDNFLSTLFTHSHNIILQLLAEMG ISGTLLVAATLLTGIAGLLKRSLTPASLFLLCALAVSMCHSMLEYPLWYVYFLIPFGLML FLSPAEASDGIAFKKAANLGILTASAAIFAGLLHLDWTYTRLVNSFSPAADDSAKTLNRK INELRYISANSPMLSFYADFSLVNFALPEYPETQTWAEEATLKALKYRPYSATYRIALYL MRQGKVAEAKQWMRATQSYYPYLMPRYADEIRKLPVWAPLLPELLKDCKAFAAAPGHPET KPCK
EMBL CDSAAW88933.1
Sequence length604 AA
Subcellular LocationMembrane (Integral component of membrane)
Glycosyltransferase Information
Glycosylation TypeO- (Ser/Thr) linked 
EC Number (BRENDA)2.4.1.-
Mechanism of Glycan TransferEn bloc
Donor TypeUndPP-diNAcBac-Gal
Donor SpecificityLipid linked sugars
Accessory GT IDProGT21.1, ProGT21.2, ProGT21.3, ProGT21.4, ProGT21.5, ProGT21.6
Glycan Information
Glycan transferreddiNAcBac 
Method of Glycan IndentificationMS/MS, NMR, MALDI
Experimental_strategiesIn vitro and In vivo  
Acceptor Subtrate Information
Acceptor Substrate name Pilin
ProGPdb ID ProGP119
Acceptor Substrate name PilE
ProGPdb ID ProGP99
Litrature
Year Of Validation2011 
Reference Jennings, M.P., Jen, F.E.C., Roddam, L.F., Apicella, M.A. and Edwards, J.L., 2011. Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells. Cellular microbiology, 13(6), pp.885-896.

Corresponding AuthorDepartments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Reference Hadjineophytou, C., Anonsen, J.H., Svingerud, T., Mortimer, T.D., Grad, Y.H., Scott, N.E. and Koomey, M., 2022. Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities. Mbio, pp.e03797-21.

Corresponding AuthorDepartment of Biosciences, Section for Genetics and Evolutionary Biology, University of Oslo, Oslo, Norway
Department of Biosciences, Centre for Ecological and Evolutionary Synthesis, University of Oslo, Oslo, Norway
Norwegian Research Centre AS, Randaberg, Norway.