ProGT28 (Lgt3)

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ProGT ID ProGT28 (Lgt3)
Organism Information
Organism NameLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Clinical ImplicationPathogenic
DomainBacteria
Classification Phylum : Firmicutes
Class : GammaProteobacteria
Orders : Legionellales
Family : Legionellaceae
Genus : Legionella
Species : pneumophila
Subspecies : pneumophila
Strain : Philadelphia 1 / ATCC 33152 / DSM 7513
Taxonomic ID (NCBI)272624
Genome Information
Gene BankAE017354.1
EMBLAE017354
Gene Information
Gene Namelgt3
Protein information
Protein NameLgt3 
UniProtKB/ SwissProt IDQ5ZVF2
NCBI Ref SeqWP_010947217.1
UniProtKB Sequence>tr|Q5ZVF2|Q5ZVF2_LEGPH Coiled-coil-containing protein OS=Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) GN=legC5 PE=4 SV=1 MKEQQKAIFIENIKSTCAVDEQMAKELADSLLEIHQLNTGVNEQTLINEVFLTKFALYLK IGKEVALDWVRKNKDLDTPFPSNTVENQPAQDAKKPVENKVQVYGAMTVGSSPVNKTLNR LTNDLLKEVVERGKTQKAQKLRAYIFDQLARRLEASLSQEQINDLYNRIRGTGDYTKSES FSEEQLKILKEKVVPELKRELSDLSNGNVNILGLDVSREDKYAFDTTNIFSVWFSNNPAV YMPQHVKTQVEKTAKLNQPGKTRIVFSSLCLNETAQIDFQQWAKENNIELVDIDSIDLKS VSETDAQLLNLAKDELGAMRKGKGGNPAAASDLVRWVDVIIGESSTYIDIDLPMNDKKVT VEVHSGFPVLLNMGSALTKDGQQPAMENPAFNTDMIAYSKDKEARRQIIEGVAKKIIARY ENCAKYIEESKNEELVRLKNSPGYKLFVEKTDGKFDLCTLRAAVSEAHQDALSFATFFGA EYFAKTFATQELIPVIKEAIQHQNQDLLTSVIENHIEKQHLNDYPKTPDGIKKLLKSFQG IVYKPLVMEFSGPSAVSSSWVEAISGRSIPRNFEYLAEPMSQPLRVLQHYACVSGKANFS SDNIPKWCELQSDVEKRQQQREDGLSWLPDAQEKLKREGQQAKLEEEQRIKLEEEQRIKL EEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEH KSKKYFAQSDAIDLILNNFENEINSIGAYYAPAKQRAIELLDTLRKYKEEAFNDPSREKL ISFAQSTKRAIQEATPILQKDLGWGDYLTNLAKQLVNAVTFAVAYAVTFGTTGHQGFFAL KSSLAVSQSQNLEGAINSELSQKNC
EMBL CDSAAU27570.1
Sequence length865 AA
Subcellular LocationHost cell plasma membrane
String272624.lpg1488.
Glycosyltransferase Information
Glycosylation TypeO- (Ser) linked 
CAZY FamilyGT88
EC Number (BRENDA)2.4.1.-
Mechanism of Glycan TransferSequential
Donor TypeUDP-Glc
Donor SpecificityNucleotide activated sugars
Glycan Information
Glycan transferredMonosaccharide (Glc) 
Method of Glycan IndentificationImmunoblot using anti-Lgt serum
Experimental_strategiesIn vitro and In vivo  
Acceptor Subtrate Information
Acceptor Substrate name EF1A
Litrature
Year Of Validation2008 
Reference Belyi, Y., Tabakova, I., Stahl, M. and Aktories, K., 2008. Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila. Journal of bacteriology, 190(8), pp.3026-3035.

Corresponding AuthorGamaleya Research Institute, Moscow 123098, Russia.
Reference Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A.F., Shepherd, S., Prescott, A., Segal, G. and van Aalten, D.M., 2010. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase. Biochemical Journal, 426(3), pp.281-292.

Corresponding AuthorDivision of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.