ProGT71 (PglLBc)
| ProGT ID | ProGT71 (PglLBc) |
| Organism Information | |
| Organism Name | Burkholderia cepacia K56-2 |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : BetaProteobacteria Orders : Burkholderiales Family : Burkholderiaceae Genus : Burkholderia Species : cenocepacia Strain : K56-2 |
| Taxonomic ID (NCBI) | 216591 |
| Genome Information | |
| Gene Bank | AM747720.1 |
| EMBL | AM747720 |
| Gene Information | |
| Gene Name | Bcal0960 |
| NCBI Reference Sequence | AM747720.1 |
| Protein information | |
| Protein Name | PglLBc |
| UniProtKB/ SwissProt ID | B4EBZ0 |
| NCBI Ref Seq | CAR51267.1 |
| UniProtKB Sequence | >tr|B4EBZ0|B4EBZ0_BURCJ O-antigen polymerase family protein OS=Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) OX=216591 GN=BCAL0960 PE=4 SV=1 MRRLLTSGSLMPSTFSRSLSLVALAVALIVPYAITNHTYPIPTFYSEFSALVLYLLVGVS VVLLARTGRPAEPFAAPAAFAVPLGFAVVLLAQVALIPLKVPSMNWLALGYLAAALVAMQ AGYALARDGMAETVWPMMAGALLVGGVFAVGTQIVQLFHLESAVSPFVVVYNIAVDRRPY GNMAQANHLASYIAFALAGALYLVQTRRLAVWAWLALSLVLSVGLALTVSRGPWLQVAVM VVAGFWMAWVESRRTPGNARAWLIPVVLAAAFIAVNVAVRWANVHYHLNLAESAADRMRD AGQIAPRLALWKYGLAMFREHPLLGVGWGEFPSHQFALVRTLGGVEIANNSHDIFIDLLA KSGLVGLGVLAVTLVAWFVRAVRAPQSSMRVFGFALFGILLMHALVEYPQQYMFFLLPAM FVIGLLDVKPLRILPGRAAFGLFAVLSFGGVLAAVPVLRDYQRAEVLYYGSSPAAQYRDA PSLLFGAWGDYGAATLLPISPDDLPAKLAAHERAIALLPGETVLRRYAVLQALAGREADA LDTVARLHVFAKELKDWPQQLAALYKLCDQEPALKTFRAAVVAKYGEAPADEGDDSDDDD SD |
| EMBL CDS | CAR51267.1 |
| Sequence length | 602 AA |
| Subcellular Location | Membrane (Integral component of membrane) |
| String | 216591.BCAL0960. |
| Additional Information | 1) PglLBc is essential for swimming motility and also required for the full virulence against Lemna minor and Galleria mellonella. |
| Glycosyltransferase Information | |
| Glycosylation Type | O- (Ser/Thr) linked |
| EC Number (BRENDA) | 2.4.1.- |
| Mechanism of Glycan Transfer | En bloc |
| Donor Type | UndPP-Trisaccharide |
| Donor Specificity | Lipid linked sugars |
| Glycan Information | |
| Glycan transferred | Trisaccharide (HexNAc-HexNAc-Hex) |
| Method of Glycan Indentification | MS/MS |
| Experimental_strategies | In vivo |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | C-terminal protease |
| ProGPdb ID | ProGP468 |
| Acceptor Substrate name | MdtA (multidrug resistance protein) |
| ProGPdb ID | ProGP469 |
| Acceptor Substrate name | Putative uncharacterized protein |
| ProGPdb ID | ProGP470 |
| Acceptor Substrate name | Putative uncharacterized protein |
| ProGPdb ID | ProGP471 |
| Acceptor Substrate name | Putative signal peptide |
| ProGPdb ID | ProGP476 |
| Acceptor Substrate name | Peptidoglycan-binding membrane protein |
| ProGPdb ID | ProGP473 |
| Acceptor Substrate name | Putative phospholipid-binding lipoprotein |
| ProGPdb ID | ProGP470 |
| Acceptor Substrate name | Putative uncharacterized protein |
| ProGPdb ID | ProGP475 |
| Acceptor Substrate name | Putative MCE (mammalian cell entry) related protein |
| ProGPdb ID | ProGP476 |
| Acceptor Substrate name | Putative cell division related protein |
| ProGPdb ID | ProGP477 |
| Acceptor Substrate name | Putative uncharacterized protein |
| ProGPdb ID | ProGP478 |
| Acceptor Substrate name | Putative lipoprotein |
| ProGPdb ID | ProGP483 |
| Acceptor Substrate name | Putative fusaric acid resistance transporter protein |
| Acceptor Substrate name | ProGP485 |
| Acceptor Substrate name | ComEA |
| ProGPdb ID | ProGP482 |
| Acceptor Substrate name | Putative PRC barrel containing lipoprotein |
| Acceptor Substrate name | Putative exported protein |
| Acceptor Substrate name | oprM efflux system outer membrane protein |
| ProGPdb ID | ProGP485 |
| Acceptor Substrate name | Putative membrane protein |
| ProGPdb ID | ProGP486 |
| Acceptor Substrate name | OM lipoprotein carrier LolA |
| ProGPdb ID | ProGP487 |
| Acceptor Substrate name | OmlA |
| ProGPdb ID | ProGP488 |
| Acceptor Substrate name | Cell division protein |
| ProGPdb ID | ProGP489 |
| Acceptor Substrate name | OmpA family protein |
| ProGPdb ID | ProGP490 |
| Acceptor Substrate name | Putative uncharacterized protein |
| ProGPdb ID | ProGP491 |
| Acceptor Substrate name | Type IV Pilin |
| ProGPdb ID | ProGP492 |
| Acceptor Substrate name | FliC (Flagellin) |
| ProGPdb ID | ProGP494 |
| Litrature | |
| Year Of Validation | 2014 |
| Reference | Lithgow, K.V., Scott, N.E., Iwashkiw, J.A., Thomson, E.L., Foster, L.J., Feldman, M.F. and Dennis, J.J., 2014. A general protein O?glycosylation system within the B urkholderia cepacia complex is involved in motility and virulence. Molecular microbiology, 92(1), pp.116-137. |
| Corresponding Author | Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada |