ProGP1160 (BCAL2640)
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP1160 (BCAL2640) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Burkholderia cenocepacia |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : Betaproteobacteria Orders : Burkholderiales Family : Burkholderiaceae Genus : Burkholderia Species : cenocepacia |
| Taxonomic ID (NCBI) | 216591 |
| Genome Information | |
| GenBank | AM747720.1 |
| EMBL | AM747720 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Gene Information | |
| Gene Name | pglL |
| Protein Information | |
| Protein Name | BCAL2640 |
| UniProtKB/SwissProt ID | B4E8D4 |
| NCBI RefSeq | CAR52942.1 |
| UniProtKB Sequence | >CAR52942.1 putative exported protein [Burkholderia cenocepacia J2315] MATHGRLRAMRAALAALVVWTAGLAGLAGAGVAHAEVAAADPIDVAMRQCLARRDRSSPAGQIQCMGEAQQQWQTVMDGAYQRLLKDAPADAKRGWQDSQRRWLTWRKDEVLLLKAVYDTTRGTAYAMSSADLQLQPVRDRALALRGAADRYAPPPAAVPVAATSGAQGGAAAAAAPAGTKPANAPREPAVRRVRPCVQDAACEHALFDLNRYYQKLRRKMPAHSAGTLVRAQRAWVAFRDATAPLVGEDGRVDLIGARIATMKRLSETAGNR |
| Function | Enhances growth under many different carbon sources as well as oxidative and osmotic stress |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Experimentally Validated Glycosite(s ) in Mature Protein | >CAR52942.1 putative exported protein [Burkholderia cenocepacia J2315] MATHGRLRAMRAALAALVVWTAGLAGLAGAGVAHAEVAAADPIDVAMRQCLARRDRSSPAGQIQCMGEAQQQWQTVMDGAYQRLLKDAPADAKRGWQDSQRRWLTWRKDEVLLLKAVYDTTRGTAYAMSSADLQLQPVRDRALALRGAADRYAPPPAAVPVAATSGAQGGAAAAAAPAGTKPANAPREPAVRRVRPCVQDAACEHALFDLNRYYQKLRRKMPAHSAGTLVRAQRAWVAFRDATAPLVGEDGRVDLIGARIATMKRLSETAGNR |
| Technique(s) used for Glycosylation Detection | NMR spectrometry |
| Protein Glycosylation- Implication | Loss of O-glycosylation is associated with growth defects under many different carbon sources as well as oxidative and osmotic stress |
| Glycan Information | |
| Glycan Structure | β-Gal-(1→3)-α-GalNAc-(1→3)-β-GalNAc-(1→) |
| Technique(s) used for Glycan Identification | NMR spectrometry and LC-MS based analyses |
| Literature | |
| Year of Identification | 2019 |
| Reference | Mohamed, Y.F., Scott, N.E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M.M., Green, H., Jones, A.M., DeShazer, D. and Currie, B.J., 2019. A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans. Journal of Biological Chemistry, 294(36), pp.13248-13268. |
| Corresponding Author | Miguel A. Valvano |
| Contact | Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast BT97BL, United Kingdom Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada |