ProGP1161 (WTA-wall teichoic acid)
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| ProGP ID | ProGP1161 (WTA-wall teichoic acid) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Listeria monocytogenes serovar 4b |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Listeriaceae Genus : Listeria Species : monocytogenes |
| Taxonomic ID (NCBI) | 1639 |
| Genome Information | |
| Organism Additional Information | It has a distinguishing ability to invade and replicate within mammalian cells |
| Protein Information | |
| Protein Name | cell wall |
| Subcellular Location | cell wall |
| Function | Cellular invasiveness and virulence the pathogen may retain GlcNAc on WTA to promote important functions related to biofilm formation, tolerance toward cleaning products and antimicrobial peptides, and possibly, to sustain virulence |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | MS analysis |
| Glycan Information | |
| Glycan Annotation | Monosaccharide (Galactose, GlcNAc) |
| Technique(s) used for Glycan Identification | UPLC-MS/MS |
| Protein Glycosylation linked (PGL) gene(s) | |
| Additional Comment | It is reported for the first time that the lack of GlcNAc on WTA protects L. monocytogenes against the antimicrobial activity of FFAs. FFAs are repelled from the bacterium in the absence of GlcNAc due to a more hydrophilic surface. Notably, FFA PA effectively inhibited the expression of PrfA-dependent genes, virulence genes, regardless of the presence or absence of WTA decorations. |
| Literature | |
| Year of Identification | 2019 |
| Reference | Sumrall, E.T., Shen, Y., Keller, A.P., Rismondo, J., Pavlou, M., Eugster, M.R., Boulos, S., Disson, O., Thouvenot, P., Kilcher, S. and Wollscheid, B., 2019. Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion. PLoS pathogens, 15(10), p.e1008032. |
| Corresponding Author | Yang Shen Martin J Loessner |
| Contact | Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland |
| Reference | Thomasen, R.S., Dos Santos, P.T., Lillebæk, E.M.S., Skov, M.N., Kemp, M. and Kallipolitis, B.H., 2022. Absence of N-Acetylglucosamine Glycosylation on Listeria monocytogenes Wall Teichoic Acids Promotes Fatty Acid Tolerance by Repulsion From the Bacterial Surface. Frontiers in Microbiology, 13, p.897682. |
| Corresponding Author | Birgitte H. Kallipolitis |
| Contact | Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark |