ProGP1165 (LspA)
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| ProGP ID | ProGP1165 (LspA) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Propionibacterium |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Propionibacteriales Family : Propionibacteriaceae |
| Taxonomic ID (NCBI) | 1743 |
| Gene Information | |
| Gene Name | lspA |
| Protein Information | |
| Protein Name | LspA |
| Subcellular Location | S-layer of cell wall |
| Function | Bacterial transcriptomic and metabolomic signaling, including differential metabolic pathways involved in peptidoglycan biosynthesis, amino and nucleotide sugar metabolism, fructose and mannose metabolism |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Technique(s) used for Glycosylation Detection | SDS-PAGE and western blotting |
| Protein Glycosylation- Implication | The glycosylation of bacterial large surface layer protein A (LspA) regulates the interaction with SIGNR1, resulting in the control of DC transcriptomic and metabolomic machineries. |
| Glycan Information | |
| Glycan Annotation | mannose |
| Technique(s) used for Glycan Identification | MALDI-MS |
| Literature | |
| Year of Identification | 2020 |
| Reference | Ge, Y., Gong, M., Zadeh, M., Li, J., Abbott, J.R., Li, W., Morel, L., Sonon, R., Supekar, N.T., Azadi, P. and Wang, Y., 2020. Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation. Mucosal immunology, 13(1), pp.34-46. |
| Corresponding Author | Mansour Mohamadzadeh |
| Contact | 1.Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA. 2.Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, 32611, USA. |