ProGP135 (37-kDa protein)
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| ProGP ID | ProGP135 (37-kDa protein) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Actinobacillus actinomycetemcomitans Y4 (serotype b) |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : Gammaproteobacteria Orders : Pasteurellales Family : Pasteurellaceae Genus : Actinobacillus Species : actinomycetemcomitans Strain : Y4 |
| Taxonomic ID (NCBI) | 714 |
| Genome Information | |
| GenBank | NZ_CP016553.1. |
| EMBL | AB011405 |
| Protein Information | |
| Protein Name | 37-kDa protein |
| Subcellular Location | Extracellular |
| Function | Plays a role in A. actinomycetemcomitans-associated periodontitis, as antigen inducing the release of inflammatory cytokines which are associated with alveolar bone loss. The IL-6-inducing activity was higher than that of LPS. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Immunoblotting using anti glycan antibodies. |
| Literature | |
| Year of Identification | 1997 |
| Year of Identification Month Wise | 1997.9 |
| Reference | Tani, Y., Tani, M. and Kato, I., 1997. Extracellular 37-kDa antigenic protein from Actinobacillus actinomycetemcomitans induces TNF-α, IL-1β, and IL-6 in murine macrophages. Journal of dental research, 76(9), pp.1538-1547. |
| Corresponding Author | Y Tani |
| Contact | Department of Periodontology, Nagasaki University School of Dentistry, Japan. |