ProGP169 (Surface layer glycoproteins)
Home -> ProGPdb -> Search ProGP -> Display data
| ProGP ID | ProGP169 (Surface layer glycoproteins) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Clostridium difficile C253 |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Clostridia Orders : Eubacteriales Family : Peptostreptococcaceae Genus : Clostridium Species : difficile Strain : SLCT-11 |
| Taxonomic ID (NCBI) | 1496 |
| Genome Information | |
| GenBank | GU048823 |
| EMBL | GU048823 |
| Organism Additional Information | Clostridium difficile is a gram-positive, anaerobic, spore-forming bacterium that produces TcdA and TcdB toxins causing severe tissue damage. It ia an opportunistic pathogen that is the major cause of antibiotic-associated diarrhoea and pseudomembranous colitis in humans. C. dificile infection can also result in abdominal pain, inflammation, and ulceration of the lining of the intestinal wall. |
| Protein Information | |
| Protein Name | Surface layer glycoproteins |
| Subcellular Location | Surface |
| Function | Two glycoproteins P36 and P47 are the components of the S-layer. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | DIG glycan/protein double labeling kit and thymol staining method. |
| Literature | |
| Year of Identification | 1999 |
| Year of Identification Month Wise | 1999.5 |
| Reference | Calabi, E., Ward, S., Wren, B., Paxton, T., Panico, M., Morris, H., Dell, A., Dougan, G. and Fairweather, N., 2001. Molecular characterization of the surface layer proteins from Clostridium difficile. Molecular microbiology, 40(5), pp.1187-1199. |
| Corresponding Author | Neil Fairweather |
| Contact | Department of Biology and Biochemistry, Imperial College, South Kensington, London SW7 2AY, UK. |
| Reference | Karjalainen, T., Waligora-Dupriet, A.J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P. and Mastrantonio, P., 2001. Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile. Infection and immunity, 69(5), pp.3442-3446. |
| Corresponding Author | Paola Mastrantonio |
| Contact | Department of Microbiology, Faculty of Pharmacy, University of Paris-Sud, 92296 Châtenay-Malabry Cedex, France |
| Reference | Cerquetti, M., Molinari, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C. and Mastrantonio, P., 2000. Characterization of surface layer proteins from different Clostridium difficile clinical isolates. Microbial pathogenesis, 28(6), pp.363-372. |
| Corresponding Author | Paola Mastrantonio |
| Contact | Department of Microbiology, Faculty of Pharmacy, University of Paris-Sud, 92296 Châtenay-Malabry Cedex, France |
| Reference | Mauri, P.L., Pietta, P.G., Maggioni, A., Cerquetti, M., Sebastianelli, A. and Mastrantonio, P., 1999. Characterization of surface layer proteins from Clostridium difficile by liquid chromatography/electrospray ionization mass spectrometry. Rapid communications in mass spectrometry, 13(8), pp.695-703. |
| Corresponding Author | P L Mauri |
| Contact | Institute of Advanced Biomedical Technologies / CNR, Segrate-Milano, Italy. |